BioWorld Science - Articles

Neurology/Psychiatric

Aeterna Zentaris updates progress of development pipeline

July 14, 2023

Aeterna Zentaris Inc. has offered an update on its development pipeline programs. Macimorelin acetate (AEZS-130), a ghrelin agonist approved and commercialized as a test for adult growth hormone deficiency, is in preclinical development for amyotrophic lateral sclerosis (ALS). The company has now successfully developed an alternative formulation suitable for use in ALS.

Neurology/Psychiatric

WPC 2023: Encoded single-chain antibodies to slow Parkinson’s disease progression

July 14, 2023

By Coia Dulsat

Given that monoclonal antibodies are so big, only 0.1% of a dose will cross the blood-brain barrier (BBB). And that’s why their utility in central nervous system (CNS) disorders management is limited.

Neurology/Psychiatric

Delix Therapeutics describes new 5-HT2A receptor modulators

July 13, 2023

Delix Therapeutics Inc. has identified pyrrolidine psychoplastogens acting as 5-HT2A receptor modulators reported to be useful for the treatment of neurodegeneration, substance abuse and dependence, impulse control, mood, sleep, anxiety, eating and personality disorders, among others.

Neurology/Psychiatric

Whanin Pharmaceutical patents new LRRK2 inhibitors

July 13, 2023

Whanin Pharmaceutical Co. Ltd. has disclosed macrocyclic pyrimidine derivatives acting as...

Neurology/Psychiatric

Raya Therapeutic and Argenx establish early-stage R&D collaboration in neurodegeneration

July 13, 2023

Raya Therapeutic Inc. has entered into an early-stage R&D collaboration with Argenx SE to evaluate combinations of Raya’s pipeline of targeted small molecules with a potentially complementary product from Argenx.

Elderly woman holding illustration of brain with missing puzzle piece

Neurology/Psychiatric

Novel TRPML1 activator SAM-001 shows reversal of PD pathology in animal models

July 13, 2023

Autophagy is an essential cellular pathway where intracellular components are degraded or...

Scientific figure illustrating astrocytes and neuron synapse

Neurology/Psychiatric

Glial cells get all-too-rare star turn at biannual meeting

July 13, 2023

By Anette Breindl

In brain research, be it basic or clinical, neurons have long hogged the limelight. But at the 2023 European Meeting on Glial Cells in Health and Disease, neurons take a back seat to glia – cell types that have often been described as support cells and treated as an afterthought, but that play critical roles in all aspects of brain function, including information processing.

Neurology/Psychiatric

Novartis discovers new Cav1.2 inhibitors

July 12, 2023

Novartis AG has described pyridine-3-carboxylate compounds acting as voltage-dependent L-type calcium channel subunit α-1C channel (Cav1.2) activators reported to be useful for the treatment of schizophrenia, major depression, attention deficit hyperactivity disorder, autism spectrum disorder, multiple sclerosis, frontotemporal dementia, Alzheimer’s disease and Brugada syndrome.

Neurology/Psychiatric