A model of tauopathy developed in the worm nematode Caenorhabditis elegans was developed for investigating the mechanisms behind tauopathy development.

Satellos Bioscience Inc. has designated SAT-3153 as a development candidate for Duchenne muscular dystrophy and will move the candidate into pre-IND-enabling studies and toward an IND filing. SAT-3153 is a small molecule designed to inhibit a particular kinase protein which the company believes controls Notch polarity within muscle stem cells.

Umecrine Cognition AB has announced results showing that its GABA-A receptor-modulating steroid antagonist golexanolone reversed fatigue, anxiety, depression, and some cognitive and motor alterations in a preclinical model of Parkinson's disease. Compared to a control-operated group, models with Parkinson's disease showed increased fatigue in the treadmill test and anxiety in the open field test.

Rewind Therapeutics NV has described 3-pyrrolylsulfonamide compounds acting as uracil nucleotide/cysteinyl leukotriene receptor (GPR17; P2Y-like) antagonists reported to be useful for diagnosis and treatment of neurodegeneration, leukodystrophies, optic neuropathy, Charcot-Marie-Tooth disease, demyelinating, psychiatric and genetic disorders, among others.

Researchers from Yale University and affiliated organizations published data from a study that aimed to assess the mechanistic and pathophysiological importance of plaque-associated axonal spheroids (PAASs) in Alzheimer’s disease (AD).

2021 was the year Aduhelm (aducanumab, Biogen Inc.) was approved as the first amyloid-β-busting drug for Alzheimer’s disease. And in 2022, there was as much need for an effective AD drug as ever. Aduhelm’s commercial fate was sealed with the decision of the Center for Medicare & Medicaid Services (CMS) that the drug would only be reimbursed in clinical trials approved by the CMS or the NIH.

Cancer both imitates and hijacks the nervous system, to the extent that some researchers consider tumor-neuronal interactions a new hallmark of cancer. Unsurprisingly, the parallels are particularly strong in brain cancers. Glioblastomas form electrically interconnected networks, similar to neuronal-glial gap junctions, that help them grow. Now, researchers have identified key players in these networks, as well as ways to target them and possibly take down the networks.