Although the development pipeline for obesity treatments is expanding rapidly, weight loss is often accompanied by a concurrent reduction in lean muscle mass, highlighting the need for novel therapeutic approaches that promote fat loss while preserving muscle. Activin type II receptors (ACTRIIA/B) are regulators of muscle homeostasis, while the glucose-dependent insulinotropic polypeptide receptor (GIPR) plays a role in energy balance and adiposity.

The National Institute of Allergy and Infectious Diseases (NIAID) has awarded a 5-year $20.8 million grant to a multi-institutional team led by Weill Cornell Medicine investigators for advanced preclinical development of a promising experimental HIV vaccine.

Two back-to-back papers published in Nature on Sept. 10, 2025, shed new light on the unexpected role of neurons in shaping the evolution of small-cell lung cancer (SCLC). It’s already known that, in gliomas, cerebral cancer cells actively damage axons, contributing to tumor progression through direct neural disruption. Comparable nerve-tumor interactions have been reported in peripheral cancers, where tumor-induced nerve disruption promotes inflammation and an immunosuppressive microenvironment linked to immunotherapy resistance.