A recent Astrazeneca AB patent describes 2,5-diazabicyclo[4.2.0]octanes and octahydrofuro[3,4-b]pyrazines acting as glucagon-like peptide 1 receptor (GLP-1R) agonists potentially useful for the treatment of type 2 diabetes.
Research at Iteos Belgium SA has led to the discovery of macrocyclic compounds acting as equilibrative nucleoside transporter ENT1 inhibitors and reported to be useful for the treatment of cancer.
2-Oxo-3-azabicyclo[3.1.0]hexane derivatives acting as ketohexokinase (KHK) inhibitors have been reported in a recent Hua Medicine Ltd. patent as potentially useful for the treatment of diabetes, fibrosis, obesity, neurological, metabolic, gastrointestinal, cardiovascular and renal diseases, among others.
GSK plc and Ideaya Biosciences Inc. have jointly developed cyclic vinyl sulfone compounds acting as Werner syndrome ATP-dependent helicase (WRN; RECQ3; RECQL2) inhibitors that are reported to be useful for the treatment of cancer.
Merck Sharp & Dohme Corp. researchers have patented targeted activator of cell kill (TACK) compounds acting as Gag polyprotein (HIV-1)/protein Pol dimerization inducers and thus reported to be useful for the treatment of HIV infection.
Recent findings in murine studies have unveiled a circuit linking the basolateral amygdala to the anterior cingulate cortex (BLA-ACC circuit) as a key for chronic pain-induced depression symptoms; researchers aimed to clarify the mechanisms behind this phenotype. Stimulation of this circuit led to the upregulation of semaphorin 4A (SEMA4A), which was the focus of the study.
Rnaimmune Inc., a nonwholly owned subsidiary of Sirnaomics Ltd., has received clearance from the FDA for its IND application to conduct a phase I trial for RV-1730, a SARS-CoV-2 vaccine booster candidate.
Therini Bio Inc. has closed a US$36 million series A financing round that will support its work on developing fibrin-targeted therapies for diseases driven by chronic inflammation, including Alzheimer’s disease, multiple sclerosis and retinal diseases such as diabetic macular edema.
Generate Biomedicines Inc. and The University of Texas MD Anderson Cancer Center have established a strategic collaboration to jointly discover and codevelop protein therapeutics for up to five oncology targets in advanced cancers, including small-cell and non-small-cell lung cancer.
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