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BioWorld - Thursday, April 23, 2026
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Dermatologic

Dice Molecules describes integrin αv/β1 and/or αv/β6 antagonists

Oct. 6, 2022
Dice Molecules SV LLC has divulged new integrin αv/β1 and/or integrin αv/β6 antagonists reported to be useful for the treatment of fibrosis, rheumatoid arthritis, diabetic nephropathy, nonalcoholic steatohepatitis, focal segmental glomerulosclerosis, primary biliary cholangitis and cancer.
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Colorized scanning electron micrograph of N. gonorrhoeae bacteria.
Infection

Intravacc awarded NIAID contract to develop prophylactic intranasal gonorrhea vaccine

Oct. 6, 2022
Intravacc BV has been awarded a contract by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), for the development of a prophylactic intranasal vaccine against Neisseria gonorrhoeae (NG), the cause of the sexually transmitted disease gonorrhea.
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Stroke illustration: brain, artery, neurons
Neurology/Psychiatric

FSAP-SPD as a new therapeutic strategy in ischemic stroke

Oct. 6, 2022
Previous studies have revealed that factor VII-activating protease (FSAP) levels are raised in patients as well as mice after stroke.
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Infection

Clarametyx receives IND clearance for novel immune-enabling antibody therapy CMTX-101

Oct. 6, 2022
Clarametyx Biosciences Inc. has received FDA clearance of its IND application for first-in-human phase I evaluation of CMTX-101, a novel...
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Cancer

TMAO promotes immune activation and enhances immune checkpoint blockade therapy in PDAC

Oct. 6, 2022
Pancreatic ductal adenocarcinoma (PDAC) is a type of cancer with poor prognosis and immunotherapy has failed at improving patient...
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Cancer research illustration
Cancer

Novel platinum (II) complexes show better antitumor efficacy than oxaliplatin

Oct. 6, 2022
Researchers from Zhejiang University of Technology presented the discovery of platinum (II) complexes with promising physicochemical...
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Neurology/Psychiatric

NIA award supports Oligomerix's development of tau self-association small-molecule inhibitor

Oct. 6, 2022
Oligomerix Inc. has been awarded US$2.49 million from the National Institute on Aging (NIA) to support clinical development of its lead...
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Cancer cells
Cancer

Model Medicines launches oncology programs targeting AXL and BRD4

Oct. 6, 2022
Model Medicines Inc. has launched oncology programs focused on the discovery and development of therapeutics against two...
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Amyloid plaques forming between neurons
Neurology/Psychiatric

Bispecific antibody targeting TREM2 and TfR reduces amyloid burden in murine AD model

Oct. 6, 2022
It is known that triggering receptor expressed on myeloid cells 2 (TREM2) plays a key role, such as regulating microglial migration or phagocytosis...
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Human aging illustration
Genetic/Congenital

Genetic influences on longevity depend on sex and age

Oct. 6, 2022
By Mar de Miguel
Researchers have gained new insights into both genetic and nongenetic factors affecting life span, and how they differ between males and females. Several genes were correlated with longevity, according to a study by the École Polytechnique Fédérale de Lausanne (EPFL). However, some did not affect life span until males reached a certain age. Early access to nutrients during growth also affected longevity, as they saw in their study of more than 3,000 mice and verified with human data. “This study is one of the biggest studies on mass longevity. We were looking for genetic determinants of longevity but there are non-genetic determinants affecting longevity,” the first author Maroun Bou Sleiman, researcher at EPFL, told Bioworld.
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