Vanda Pharmaceuticals Inc. and Olipass Corp. have entered into a research and development collaboration agreement to jointly develop a set of antisense oligonucleotide (ASO) molecules based on Olipass' proprietary modified peptide nucleic acids.

A research consortium comprised of XL-protein GmbH, Wacker Chemie AG and Ludwig-Maximilians-Universität München (LMU) will develop a novel long-acting immunosuppressive anti-CD40 antibody fragment for the selective suppression of organ rejection, in particular in the area of cardiac xenotransplantation.

While simultaneous targeting of PD-1 and TGF-β has been previously suggested to be a favorable strategy to reverse immune checkpoint inhibitor (ICI) resistance of tumors, the hydrophobicity of TGF-β inhibitors and latent drug-related adverse events of this treatment hindered its utility.

Researchers from the University of Coimbra presented data from a study that aimed to assess the role of the ghrelin/neuropeptide Y (NPY) system in adipose tissue in subjects with obesity and metabolic syndrome.

Cell cycle-associated protein 1 (CAPRIN1) is an ubiquitously expressed protein, the levels of which are usually high in tissues with an elevated cell turnover; it is also abundant in the brain, where it regulates the transport and translation of synaptic protein mRNA.

Maxwell Biosciences Inc. has announced data on the utility of its Claromer drug discovery platform for the treatment and prevention of SARS-CoV-2, and potentially other respiratory viruses, through a series of preclinical in vitro and in vivo studies.

New research indicates faults in repairing DNA breaks that are caused by oxidative stress in the noncoding parts of the genome are directly involved in the development of neurological diseases. The discovery of the significance of problems in repairing single-strand breaks in ‘junk’ DNA opens up a new area of biology that will lead on to new drug targets, according to Sherif El-Khamisy, professor of molecular medicine and deputy director of the Health Lifespan Institute at the University of Sheffield, U.K., who is co-author of a Sept. 29, 2022, paper in Nature describing the discovery of a gene that sits at the heart of the repair process.