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BioWorld - Wednesday, March 4, 2026
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Cancer

Shenzhen Zhongge Biotechnology describes new EIF2B activators

Feb. 19, 2025
Shenzhen Zhongge Biotechnology Co. Ltd. has identified translation initiation factor 2B (EIF2B) activators reported to be useful for the treatment of autoimmune disease, cancer, viral infection, neurodegeneration, metabolic diseases, and eye, dermatological and inflammatory disorders, among others.
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Cancer

Haisco Pharmaceutical discovers new WRN inhibitors

Feb. 19, 2025
Haisco Pharmaceutical Group Co. Ltd. has described Werner syndrome ATP-dependent helicase (WRN; RECQ3; RECQL2) inhibitors reported to be useful for the treatment of cancer.
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Nephrology

New CYP11B2 inhibitors disclosed in Hansoh patent

Feb. 19, 2025
Jiangsu Hansoh Pharmaceutical Group Co. Ltd. and Shanghai Hansoh Biomedical Co. Ltd. have divulged cytochrome P450 11B2, mitochondrial (CYP11B2; aldosterone synthase; ALDOS) inhibitors reported to be useful for the treatment of chronic kidney disease, diabetic nephropathy, congestive heart failure, hypertension, primary aldosteronism, Cushing syndrome, kidney and myocardial fibrosis.
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Inflammatory

Beijing Synthetic Vaccine Biosciences divulges new TLR8 agonists

Feb. 19, 2025
Beijing Synthetic Vaccine Biosciences Co. Ltd. has synthesized Toll-like receptor 8 (TLR8) agonists reported to be useful for the treatment of autoimmune disease, cancer, inflammatory disorders and viral infection.
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Neurology/psychiatric

Shanghai Wennai Pharmaceutical Technology patents new Nav1.8 blockers

Feb. 19, 2025
Shanghai Wennai Pharmaceutical Technology Co. Ltd. has disclosed sodium channel protein type 10 subunit α (SCN10A; Nav1.8) blockers reported to be useful for the treatment of acute and chronic pain.
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Cardiovascular illustration
Cardiovascular

Integrin α5β1 is target for pulmonary arterial hypertension

Feb. 19, 2025
Researchers from Morphic Therapeutic Inc. and affiliated organizations published data from a study that aimed to assess the potential of using arginylglycylaspartic acid (RGD) integrins for the treatment of cardiovascular diseases, such as pulmonary arterial hypertension (PAH).
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Immuno-oncology

Ona advances ADCs for solid tumors toward clinic

Feb. 19, 2025
Ona Therapeutics SL is accelerating development of its first-in-class antibody-drug conjugate (ADC) therapeutics, targeting novel tumor-specific markers to eliminate hard-to-treat, resistant cancer cells for multiple large solid tumor types.
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Novel coronavirus SARS-CoV-2
Infection

KVX-053 alleviates acute lung injury in COVID-19

Feb. 19, 2025
Researchers from Kevirx Inc. and collaborators have described the use of KVX-053, a PTP4A3 inhibitor aimed to be used for the prevention of COVID-19-associated cute lung injury (ALI).
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Three alpacas
Immuno-oncology

Camelid-based CAR T cells targeting CD33 in acute myeloid leukemia

Feb. 19, 2025
In a recently published study, researchers from Cima Universidad de Navarra and collaborators presented a novel SdAb-based CAR T-cell discovery platform that allows the generation, characterization and selection of SdAbs by several properties.
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Endocrine/metabolic

Septerna to change candidate for hypoparathyroidism

Feb. 19, 2025
Septerna Inc. has announced its decision to discontinue a healthy volunteer phase I trial of SEP-786, an oral small-molecule agonist of the parathyroid hormone 1 receptor being developed for the treatment of hypoparathyroidism.
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