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BioWorld - Tuesday, February 10, 2026
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Immuno-oncology

SYS-6045 cleared for clinic in China for advanced solid tumors

Jan. 8, 2025
CSPC Pharmaceutical Group Ltd.’s antibody-drug conjugate SYS-6045 has been granted clearance by China’s National Medical Products Administration (NMPA) to enter clinical trials.
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Immuno-oncology

Avenzo licenses ex-China rights to Duality’s EGFR/HER3 bispecific ADC

Jan. 8, 2025
Avenzo Therapeutics Inc. and Duality Biotherapeutics (Suzhou) Co. Ltd. have entered into an exclusive license agreement.
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Euro symbol in piggy bank
Neurology/psychiatric

Series A at Neumirna supports RNA therapies for neurological disorders

Jan. 8, 2025
A €20 million (US$20.6 million) series A financing round at Neumirna Therapeutics ApS is set to support the company’s development of RNA therapies for epilepsy, Parkinson’s disease and other neurological disorders, and enable the company to advance its lead asset into the clinic.
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Photo of older woman holding hand that's colored red
Inflammatory

mPGES-1 inhibitor AGU-654 is anti-inflammatory and analgesic

Jan. 8, 2025
Researchers from Gazi University and Friedrich-Schiller-Universität Jena presented the discovery and preclinical characterization of novel microsomal prostaglandin E2 synthase 1 (mPGES-1) inhibitors as potential anti-inflammatory and analgesic drug candidates.
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Lungs
Respiratory

SYH-2059 to enter trials in China for interstitial lung disease

Jan. 8, 2025
CSPC Pharmaceutical Group Ltd. has obtained clearance from China’s National Medical Products Administration (NMPA) to conduct clinical trials in China of SYH-2059 tablets for interstitial lung disease, including idiopathic pulmonary fibrosis and progressive pulmonary fibrosis.
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Illustration of a cluster of ovarian cancer cells
Cancer

New AI-based models better than humans at diagnosing ovarian cancer

Jan. 7, 2025
By Shani Alexander
Artificial intelligence (AI)-based models developed by a team of international researchers were able to identify ovarian cancer in ultrasound images more accurately than humans. Results from a study published in Nature Medicine showed that the AI models achieved an accuracy rate of 86.3%, compared to 82.6% for the experts and 77.7% for the non-expert examiners.
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Endocrine/metabolic

Dual and triple agonists of GCG, GIP and GLP-1 receptors disclosed in Sun Pharmaceutical patent

Jan. 7, 2025
Sun Pharmaceutical Industries Ltd. has divulged incretin analogues acting as dual agonists of gastric inhibitory polypeptide (GIPR) receptor/GLP-1 or GLP-1/glucagon receptor (GCGR) or triple agonists of GIPR/GLP-1/GCGR reported to be useful for the treatment of type 2 diabetes, dyslipidemia, obesity, metabolic syndrome, neurodegeneration, fibrosis and cardiovascular disorders.
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Infection

Zydus Lifesciences discovers new compounds to treat dengue virus infection

Jan. 7, 2025
Zydus Lifesciences Ltd. has described compounds reported to be useful for the treatment of dengue virus infections.
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Gastrointestinal

Flagship Pioneering Innovations VI divulges new CD38 inhibitors

Jan. 7, 2025
Flagship Pioneering Innovations VI LLC has synthesized ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) inhibitors.
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Endocrine/metabolic

Chinese scientists describe new IRAK-4 degradation inducers

Jan. 7, 2025
Scientists at Apichope Bio Pharmaceutical Co. Ltd., Guangzhou Lianrui Pharmaceutical Co. Ltd. and Guangzhou Runlin Pharmaceutical Technology Co. Ltd. have identified proteolysis targeting chimeras (PROTACs) comprising an E3 ubiquitin ligase cereblon (CRBN) binding moiety coupled to an interleukin-1 receptor-associated kinase 4 (IRAK-4) targeting moiety via a linker acting as IRAK-4 degradation inducers.
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