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BioWorld - Saturday, June 20, 2026
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Cancer

Hanmi Pharmaceutical discovers new SOS1 inhibitors

April 23, 2025
Hanmi Pharmaceutical Co. Ltd. has described son of sevenless homolog 1 (SOS1) inhibitors reported to be useful for the treatment of cancer.
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Cancer

MEN1/MLL interaction inhibitors disclosed in Beyond Therapeutics patent

April 23, 2025
Beyond Therapeutics Co. Ltd. has divulged menin (MEN1)/MLL interaction inhibitors reported to be useful for the treatment of cancer.
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Neurology/psychiatric

Bayer describes new α2C-adrenoceptor antagonists

April 23, 2025
Bayer AG has identified α2C-adrenoceptor antagonists reported to be useful for the treatment of dysphagia, snoring, neurodegeneration, neuroinflammation and cardiovascular disorders.
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Gastrointestinal

Bristol Myers Squibb divulges new RIPK1 inhibitors

April 23, 2025
Bristol Myers Squibb Co. has synthesized receptor-interacting serine/threonine-protein kinase 1 (RIPK1; RIP-1) inhibitors reported to be useful for the treatment of inflammatory bowel disease, psoriasis, rheumatoid arthritis, nonalcoholic or metabolic dysfunction-associated steatohepatitis (NASH/MASH), multiple sclerosis, amyotrophic lateral sclerosis, heart failure and Alzheimer’s disease.
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Inflammatory

Chengdu Chipscreen Pharmaceutical patents new integrin αvβ1 and αvβ6 antagonists

April 23, 2025
Chengdu Chipscreen Pharmaceutical Ltd. has disclosed integrin αvβ1 and/or αvβ6 antagonists reported to be useful for the treatment of fibrosis.
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Researcher looking through a microscope
Neurology/psychiatric

Preclinical validation of [11C]KIn-83 PET tracer

April 23, 2025
α7 nicotinic acetylcholine receptors (α7nAChRs), expressed in neurons and astrocytes at lower levels, have been implicated in neuroinflammatory and neurodegenerative processes associated with Alzheimer’s disease (AD). Evidence suggests that α7nAChRs interact with soluble amyloid-β (Aβ), contributing to reactive astrogliosis and formation of Aβ plaques in AD.
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Lungs
Respiratory

MARCKS protein is potential target in equine asthma model

April 23, 2025
A recent study in Respiratory Research further investigated the expression and role of the myristoylated alanine-rich C kinase substrate (MARCKS) protein in a horse model of asthma.
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Cancer

The NSUN5-GLS axis promotes cholangiocarcinoma progression

April 23, 2025
Researchers from Shanghai Electric Power Hospital have presented a study investigating NSUN5-mediated m5C modification in cholangiocarcinoma.
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Immune

Nanobody against mpox virus: from screening to crystal structure

April 23, 2025
Researchers at the Chinese Academy of Medical Sciences and Peking Union Medical College have prepared a nanobody against mpox virus.
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Substance use & poisoning

CREG1 protects against acetaminophen-induced liver damage by regulating autophagy

April 23, 2025
Acetaminophen (APAP), although recognized as a safe and effective antipyretic and analgesic drug, can lead to acute liver failure if taken in excess.
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