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Brush scrubbing brain figurine with soap
Neurology/Psychiatric

Studies bring insights into brain’s self-cleaning mechanisms

Feb. 28, 2024
By Anette Breindl
Separate teams of investigators have reported new insights into how the brain disposes of metabolic waste via the glia-based lymphatic system, or glymph system. In two papers published in Nature on Feb. 28, 2024, scientists from Washington University in St. Louis described how in sleeping animals, the synchronized activity of neurons drove ionic gradients that facilitated the movement of fluid through brain tissue. And researchers from the Massachusetts Institute of Technology showed that, in a mouse model of Alzheimer’s disease (AD), the glymphatic system mediated clearance of amyloid-β after sensory stimulation at a 40-Hertz rhythm.
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Cancer

Hangzhou Zhongmei Huadong Pharmaceutical discovers new GTPase KRAS inhibitors for cancer

Feb. 28, 2024
Hangzhou Zhongmei Huadong Pharmaceutical Co. Ltd. has described GTPase KRAS (G12D mutant) inhibitors reported to be useful for the treatment of cancer.
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Gastrointestinal

Heptares Therapeutics presents new prostaglandin EP4 agonists for gastrointestinal and respiratory disorders

Feb. 28, 2024
Heptares Therapeutics Ltd. has divulged pyrrolidine-2-carboxamide derivatives and morpholine-3-carboxamide derivatives acting as prostaglandin E2 receptor EP4 subtype (PTGER4; EP4) agonists reported to be useful for the treatment of gastrointestinal and respiratory disorders.
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Gastrointestinal

US researchers describe new GABA(A) receptor positive allosteric modulators for GI disorders

Feb. 28, 2024
Scientists at Johns Hopkins University and The Lieber Institute for Brain Development have identified peripherally restricted GABA(A) receptor subunits α3β2γ2S (GABRA3) positive allosteric modulators reported to be useful for the treatment of inflammatory bowel disease, lactose intolerance and abdominal pain.
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Cancer

Arvinas Operations divulges new TYK2 degradation inducers

Feb. 28, 2024
Arvinas Operations Inc. has synthesized proteolysis targeting chimera (PROTAC) compounds comprising a cereblon (CRBN)-binding moiety covalently linked to a non-receptor tyrosine-protein kinase TYK2-targeting moiety via linker.
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Cancer

Iambic Therapeutics patents new CDK inhibitors for ovarian and breast cancer

Feb. 28, 2024
Iambic Therapeutics Inc. has disclosed quinazoline compounds acting as cyclin-dependent kinase (CDK) inhibitors, particularly CDK2 and/or CDK4 and/or CDK6 inhibitors reported to be useful for the treatment of ovarian and breast cancer.
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CAR T cell with implanted gene strand
Neurology/Psychiatric

Murine model recapitulates CAR T-cell therapy-induced ICANS

Feb. 28, 2024
Cancer patients receiving CAR T-cell therapy may develop and adverse event known as immune effector cell-associated neurotoxicity syndrome (ICANS).
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Eye, DNA double helix illustration.
Ocular

Pulsesight Therapeutics launches to develop non-viral gene therapies for retinal diseases

Feb. 28, 2024
Pulsesight Therapeutics SAS has launched with seed financing, with the aim of developing disruptive non-viral gene therapies with minimally invasive delivery technology.
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Cancer

POLQ tied to olaparib resistance in prostate cancer, study finds

Feb. 28, 2024
PARP inhibitors such as olaparib are used for the treatment of metastatic castration-resistant prostate cancer (mCRPC) harboring homologous recombination deficiency (HRD), but a proportion of these patients do not respond to therapy or eventually develop resistance.
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3D cross-section illustration of muscle anatomy
Neurology/Psychiatric

Arthex’s ATX-01 receives FDA clearance for first-in-human study in myotonic dystrophy type 1

Feb. 28, 2024
Arthex Biotech SL has received FDA clearance to initiate the phase I/IIa Arthemir study of ATX-01 for the treatment of myotonic dystrophy type 1 (DM1).
Read More
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