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Cancer

Discovery of potent MALT1 inhibitors with synergetic antitumor effects in models of B-cell lymphoma

March 12, 2024
Researchers from Shanghai Institute of Materia Medica of the Chinese Academy of Sciences and affiliated organizations published preclinical data for a new class of mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) inhibitors being developed as candidates for the treatment of lymphoma.
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Concept art for "unlocking the secrets of the mind"
Neurology/Psychiatric

AD/PD 2024: Insights into biological processes underlying neuronal dysfunction

March 11, 2024
By Coia Dulsat
The third day of the AD/PD 2024 conference in Lisbon started with a plenary lecture given by Professor Howard Fillit entitled, “Translating the biology of aging into new therapeutics for Alzheimer’s disease.” Fillit, a recognized neuroscientist and geriatrician, and co-founder of the Alzheimer’s Drug Discovery Foundation (ADDF), pointed to the geroscience hypothesis which postulates that targeting aging processes may result in preventive and therapeutic options for diseases of old age, including Alzheimer’s disease (AD).
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Cancer

Kymera Therapeutics discovers new CDK2 degradation inducers for cancer

March 11, 2024
Kymera Therapeutics Inc. has described proteolysis targeting chimeras (PROTAC) compounds comprising an E3 ubiquitin ligase cereblon (CRBN)-binding moiety covalently linked to a cyclin-dependent kinase 2 (CDK2)-targeting moiety through a linker.
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Cancer

Fochon Biosciences presents new Bcl-2 mutant inhibitors

March 11, 2024
Fochon Biosciences Ltd. has divulged apoptosis regulator Bcl-2 (D103E mutant and D103Y mutant) inhibitors reported to be useful for the treatment of autoimmune disease and cancer.
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Cancer

Hotspot Therapeutics describes new MALT1 inhibitors for cancer

March 11, 2024
Hotspot Therapeutics Inc. has identified mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) inhibitors reported to be useful for the treatment of cancer.
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Nephrology

Mironid divulges new phosphodiesterase PDE4 activators

March 11, 2024
Mironid Ltd. has synthesized phosphodiesterase PDE4 activators reported to be useful for the treatment cancer, hyperparathyroidism, autosomal dominant polycystic kidney disease and autosomal recessive polycystic kidney disease.
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Cancer

Astrazeneca patents new myeloperoxidase inhibitors

March 11, 2024
Astrazeneca AB has disclosed myeloperoxidase inhibitors reported to be useful for the treatment of cancer, cardiovascular, inflammatory, renal, neurological and respiratory disorders and liver diseases.
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Illustration of stomach, beneficial gut bacteria.
Neurology/Psychiatric

Intermittent fasting leads to changes in gut-associated immune cells, microbial metabolites in EAE mice

March 11, 2024
Intermittent fasting (IF) consists of fasting and refeeding cycles that cause dramatic changes in the gut microbiome and microbiota-derived metabolites, subsequently affecting immune response.
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Woman wearing eye mask while sleeping
Neurology/Psychiatric

Cuprizone-driven demyelination impacts sleep architecture in rodents, study shows

March 11, 2024
Patients with multiple sclerosis have an increased prevalence of sleep disorders compared to the general population, with an estimated rate ranging from 25% to 50% and negative impacts on quality of life.
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Silhouettes
Neurology/Psychiatric

Boehringer Ingelheim and Sosei collaborate on GPR52 agonists for schizophrenia

March 11, 2024
Boehringer Ingelheim Pharma GmbH & Co KG and Sosei Group Corp. have entered a global collaboration and exclusive option-to-license agreement in schizophrenia.
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