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Cardiovascular

Neomorph and Novo Nordisk collaborate on molecular glue degraders for cardiometabolic and rare diseases

Feb. 27, 2024
Neomorph Inc. has entered into a collaboration and licensing agreement with Novo Nordisk A/S to discover, develop and commercialize molecular glue degraders.
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Immuno-oncology

Bispecific antibody outperforms current anti-PD-1/PD-L1 agents

Feb. 27, 2024
Researchers from Compass Therapeutics Inc. reported on the preclinical characterization of CTX-8371, a bispecific tetravalent antibody that presented synergistic anti-PD-1/PD-L1 activity.
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Syringe and vial
Immune

Limmatech’s gonorrhea vaccine candidate supported by CARB-X funding

Feb. 27, 2024
Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator (CARB-X) has awarded US$ 2.2 million to Limmatech Biologics AG to advance the development of its novel vaccine candidate to prevent Neisseria gonorrhoeae infections.
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NLRP3 inflammasome
Neurology/Psychiatric

Transthera’s CNS-penetrating NLRP3 inflammasome inhibitor enters IND-enabling studies

Feb. 27, 2024
Transthera Sciences (Nanjing) Inc. has announced the initiation of IND-enabling studies for TT-02332, a potent, selective and highly CNS-penetrating NLRP3 inflammasome inhibitor.
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Photomicrograph of bone marrow aspirate showing myeloblasts of acute myeloid leukemia
Immuno-oncology

Kling Biotherapeutics’ KBA-1413 recognizes a specific form of CD43 useful for cancer

Feb. 27, 2024
Kling Biotherapeutics BV has presented preclinical data on an antibody, KBA-1413, which recognizes a specific glycoform of CD43 that is shared among acute myeloid leukemia (AML), myelodysplastic syndrome (MDS) and solid tumor cells.
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Immune

IGNX-001 prevents severe anaphylactic response to peanut challenge in mice

Feb. 27, 2024
Iggenix Inc. presented preclinical data for the novel allergen-specific antibody IGNX-001, being developed for the treatment of peanut allergy.
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AI-generated image of blood cells in a bone marrow biopsy
Hematologic

Iron rheostat turns on blood stem cells

Feb. 27, 2024
By Mar de Miguel
Iron regulates the metabolism of hematopoietic stem cells (HSCs) and acts as a genetic control of their fate, preserving their identity and regenerative capacity during tissue maintenance and repair. A group of scientists at Albert Einstein College of Medicine has described the key components of a molecular pathway that iron regulates. “What we are proposing here with this mechanism is that iron serves like a switchboard and a sensor,” senior author Britta Will told BioWorld. Will is at the Department of Oncology, the Cell Biology Department, and the Ruth and David Gottesman Institute for Stem Cell Research and Regenerative Medicine at Albert Einstein College of Medicine.
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Neurology/Psychiatric

US Department of Health and Human Services discovers new opioid receptor modulators for pain

Feb. 26, 2024
U.S. Department of Health and Human Services has described opioid receptor modulators reported to be useful for the treatment of pain.
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Endocrine/Metabolic

1910 Genetics presents new TYK2 inhibitors

Feb. 26, 2024
1910 Genetics Inc. has divulged non-receptor tyrosine-protein kinase TYK2 (JH2 domain) inhibitors reported to be useful for the treatment of allergy, cancer, inflammation, autoimmune disease, metabolic diseases, endocrine and neurological disorders.
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Immuno-oncology

Zeno Management describes new ROR1-targeting ADCs for cancer

Feb. 26, 2024
Zeno Management Inc. has identified antibody-drug conjugates comprising antibodies targeting inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) covalently bound to exatecan derivatives through a linker.
Read More
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