Zhejiang University of Technology has reported preclinical safety data for the novel multitargeting compound XYY-CP1106, being developed for the treatment of Alzheimer’s disease (AD). XYY-CP1106 is a multitargeted anti-AD compound that has previously demonstrated strong monoamine oxidase B (MAO-B) inhibition (IC50=14.7 nM), high Fe3+ chelation (pFe3+=18.04), no in vitro cytotoxicity and protection against cellular oxidative damage.

Researchers from the Center for Applied Medical Research (CIMA) in Spain have published preclinical data for two new histone deacetylase (HDAC) inhibitors – CM-444 and CM-1758 – being developed for the treatment of acute myeloid leukemia (AML).

Additional early-stage research and drug discovery news in brief, from: Igc Pharma, Io Therapeutics.

Astrazeneca AB has disclosed imidazo[4,5-b]pyridine derivatives acting as proprotein convertase subtilisin/kexin-type 9 (PCSK9) inhibitors.

Daiichi Sankyo Co. Ltd. has prepared and tested new 2-azabicyclo[3.1.1]heptane compounds acting as orexin OX2 receptor agonists with potential for the treatment of narcolepsy.