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BioWorld - Friday, March 27, 2026
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Other news to note for April 30, 2024

April 30, 2024
Additional early-stage research and drug discovery news in brief, from: Alterity Therapeutics, Hyundai Bioscience.
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Holiday notice

April 30, 2024
In accordance with the publishing schedule, BioWorld Science will not be published on Wednesday, May 1, 2024.
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Cancer

Jaguahr Therapeutics reports new AhR antagonists for treatment of cancer

April 30, 2024
A Jaguahr Therapeutics Pte Ltd. patent describes new aryl hydrocarbon receptor (AhR) antagonists reported to be useful for the treatment of cancer.
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Ocular

cGAS inhibitors described in Bellbrook Labs patent

April 30, 2024
Work at Bellbrook Labs LLC has led to the discovery of imidazolyl-alkoxyquinolin-2-amines acting as cyclic GMP-AMP synthase (MB21D1; cGAS) inhibitors.
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Cancer

Hotspot Therapeutics patents CBL-B inhibitors

April 30, 2024
Hotspot Therapeutics Inc. has identified new E3 ubiquitin-protein ligase CBL-B inhibitors reported to be useful for the treatment of cancer.
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Infection

Bluejay Therapeutics identifies new compounds for bacterial and viral infections

April 30, 2024
New indazole pyridone compounds and their prodrugs have been patented by Bluejay Therapeutics Inc.
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Cancer

Prelude Therapeutics patent details CDK inhibitors for cancer

April 30, 2024
Prelude Therapeutics Inc. has described new CDK2/cyclin E2 and CDK4/cyclin D1 inhibitors reported to be useful for the treatment of cancer.
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2D nanoparticles
Drug design, drug delivery & technologies

Repertoire, BMS to develop tolerizing vaccines for autoimmune diseases

April 30, 2024
Repertoire Immune Medicines Inc. has entered a multiyear strategic collaboration with Bristol Myers Squibb Co. (BMS) to develop tolerizing vaccines for up to three autoimmune diseases.
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Cancer cells under magnifying glass
Cancer

CKD Pharm’s c-Met-targeting CKD-703 induces cancer cell death in solid tumors

April 30, 2024
Chong Kun Dang Pharm (CKD Pharm) has presented data on their c-Met-targeting antibody-drug conjugate (ADC) CKD-703 for the treatment of solid tumors. CKD-703 was designed based on site-specific conjugation, with a stable and homogeneous drug-antibody ratio profile.
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Antibody-drug conjugate illustration
Immuno-oncology

AT-2604, an anti-ALPP/ALPPL2 ADC with efficacy and improved safety

April 30, 2024
Researchers from Axcynsis Therapeutics Pte. Ltd. presented the development and preclinical characterization of AT-2604, a novel antibody-drug conjugate (ADC) targeting the placental alkaline phosphatases, ALPP and ALPPL2.
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