Cukurova University and the University of Alicante have synthesized new 2-(pyrrolidin-1-yl)thiazole compounds reported to be useful for the treatment of bacterial infections and tuberculosis.
Nextgen Bioscience Co. Ltd. describes new compounds acting as hypoxia inducible factor-1α (HIF-1α) or vascular endothelial growth factor receptor (VEGFR) inhibitors and reported to be useful for the treatment of stroke, cancer, obesity, asthma, glaucoma, inflammatory bowel disease, rheumatoid arthritis and Alzheimer’s disease, among others.
F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. have identified new monoglyceride lipase (MGLL; MAGL) inhibitors reported to be useful for the treatment of pain, cancer, inflammatory bowel disease, endometriosis, asthma, mental diseases and neurological and renal disorders.
Astellas Pharma Inc. has patented new proteolysis targeting chimeras (PROTACs) comprising a cereblon E3 ubiquitin ligase-binding moiety coupled to GTPase KRAS (G12V mutant)-targeting agent through a linker.
Researchers from Nanjing University and affiliated organizations have published the outcomes of a study that aimed to investigate the role of cadherin 4 (CDH4) in the metastatic cascade of papillary thyroid cancer (PTC).
Children’s Hospital Los Angeles (CHLA) has received a multiyear $6 million award from the California Institute for Regenerative Medicine (CIRM) to develop innovative stem cell approaches to treat children and adolescents with recurrent solid tumors. The CIRM funding will support further CHLA research into harnessing chimeric antigen receptor (CAR) T-cell therapy.
Scientists from First Affiliated Hospital Bengbu Medical College and affiliated organizations have studied the role of the RNA-binding ubiquitin ligase MEX3C in lung adenocarcinoma (LUAD).
C4 Therapeutics Inc. has entered into a license and collaboration agreement with Merck KGaA to discover two targeted protein degraders against critical oncogenic proteins.
RSS
