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BioWorld - Thursday, February 19, 2026
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Immuno-oncology

Biomunex signs license agreement with Institut Curie for MAIT engagers

March 5, 2024
Biomunex Pharmaceuticals SAS has signed an exclusive license and exploitation agreement with Institut Curie for the development of a new class of antibodies.
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Lung cancer illustration
Cancer

DLGAP5 identified as new prognostic biomarker and therapeutic target for LUAD

March 5, 2024
Scientists from Sun Yat-sen University Cancer Center (SYSUCC) and affiliated organizations have reported data from a study that assessed the role of discs large-associated protein 5 (DLGAP5) in lung adenocarcinoma (LUAD).
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Illustration of kidney with DNA structures
Nephrology

Fibrocor Therapeutics collaborates with MSRD to advance candidate for Alport syndrome

March 5, 2024
Fibrocor Therapeutics Inc. has entered into a research and development collaboration with the Mcquade Center for Strategic Research and Development LLC (MSRD).
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Brain
Neurology/Psychiatric

Brain-penetrant TYK2 inhibitor shows efficacy in models of neuroinflammation

March 5, 2024
Researchers from Alumis Inc. have presented preclinical data for a novel, potential first-in-class tyrosine kinase 2 (TYK2) inhibitor – A-005.
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Neonatal/Pediatrics

3D organoids arising from amniotic fluid cells may be a potent prenatal tool

March 5, 2024
By Xavier Bofill Bruna
Organoids are 3D models created from human stem cells and resemble fetal tissues. In an article published in Nature Medicine on March 4, 2024, researchers from University College London provided details on the possibility of generating organoids from epithelial cells collected from amniotic fluid without terminating the pregnancy.
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Other news to note for March 4, 2024

March 4, 2024
Additional early-stage research and drug discovery news in brief, from: Defence Therapeutics.
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Infection

Cukurova University and the University of Alicante identify new compounds for bacterial infections and tuberculosis

March 4, 2024
Cukurova University and the University of Alicante have synthesized new 2-(pyrrolidin-1-yl)thiazole compounds reported to be useful for the treatment of bacterial infections and tuberculosis.
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Neurology/Psychiatric

Nextgen Bioscience patents compounds acting as HIF-1α or VEGFR inhibitors

March 4, 2024
Nextgen Bioscience Co. Ltd. describes new compounds acting as hypoxia inducible factor-1α (HIF-1α) or vascular endothelial growth factor receptor (VEGFR) inhibitors and reported to be useful for the treatment of stroke, cancer, obesity, asthma, glaucoma, inflammatory bowel disease, rheumatoid arthritis and Alzheimer’s disease, among others.
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Neurology/Psychiatric

NLRP3 inflammasome inhibitors reported in Takeda patent

March 4, 2024
Takeda Pharmaceutical Co. Ltd. has disclosed new heterocyclic compounds acting as NLRP3 inflammasome inhibitors.
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Neurology/Psychiatric

Roche prepares and tests new MAGL inhibitors

March 4, 2024
F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. have identified new monoglyceride lipase (MGLL; MAGL) inhibitors reported to be useful for the treatment of pain, cancer, inflammatory bowel disease, endometriosis, asthma, mental diseases and neurological and renal disorders.
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