Novel nicotinamide phosphoribosyltransferase (NAMPT) positive allosteric modulators (N-PAMs) have been discovered and evaluated by University of Illinois and University of Arizona investigators.

One-third of patients with acute myeloid leukemia (AML) present mutations in the FMS-like tyrosine kinase 3 (FLT3) gene. Several first- and next-generation FLT3 inhibitors are currently being used in AML management, but there is a need for new options able to achieve complete and sustained FLT3 signaling suppression.

To combat trypanosomiasis and leishmaniasis, researchers from the University of Modena and Reggio Emilia and collaborators conducted a study focusing on pteridine reductase 1 (PTR1), a catalytic protein crucial to the folate metabolic pathway in Trypanosomatid parasites.

Psilera Inc. has selected behavioral variant frontotemporal dementia (FTD) as the lead...