LONDON – A pilot study has shown that whole genome sequencing can pinpoint the genetic causes of rare diseases, even in people who had previously not been given a diagnosis after undergoing sequencing of their protein coding exome.
In a recent study, a team of researchers at the University of Washington and Seattle Children's Research Institute have discovered that spiny mice can regenerate severely damaged internal organs that, in other mice, would lead to fatal organ failure.
LONDON – Researchers have pinpointed a little-studied gene as responsible for doubling the risk of respiratory failure in COVID-19 and shown exactly how it exerts its effect. The gene, leucine zipper transcription factor like 1, is activated by a single base pair change on chromosome 3 that occurs in 60% of people of South Asian ancestry and 15% of people of European ancestry.
Investigators at Northwestern University’s Feinberg School of Medicine have used a new mouse model of Parkinson’s disease to confirm a causal role for mitochondrial dysfunction in Parkinson’s disease. More surprisingly, the same model has called into question previously uncontroversial notions about the motor features that are PD’s most conspicuous feature.
The sprint of fighting COVID-19 has been in respiratory medicine. For patients who become acutely ill, the short-term danger is in respiratory failure. But increasingly, it seems like the pandemic’s marathon fight may come to be against the neurological symptoms of COVID-19.
An international study led by U.S. oncologists at Children's Hospital of Philadelphia has successfully used a new antibody discovery platform developed by Myrio Therapeutics of Melbourne, Australia, to help identify and target key drivers of neuroblastoma in mouse models, the authors reported in the November 3, 2021, issue of Nature.
LONDON – Researchers have pinpointed a little-studied gene as responsible for doubling the risk of respiratory failure in COVID-19 and shown exactly how it exerts its effect. The gene, leucine zipper transcription factor like 1, is activated by a single base pair change on chromosome 3 that occurs in 60% of people of South Asian ancestry and 15% of people of European ancestry.
Investigators at Northwestern University’s Feinberg School of Medicine have used a new mouse model of Parkinson’s disease to confirm a causal role for mitochondrial dysfunction in Parkinson’s disease. More surprisingly, the same model has called into question previously uncontroversial notions about the motor features that are PD’s most conspicuous feature.
By using an unsupervised machine learning approach to look at genetic variation across the protein-coding genomes of 140,000 species, researchers at Harvard Medical School and Oxford University have developed a new variant classifying system that performed on a par with wet lab approaches.
A study led by researchers at the Shanghai Institute of Materia Medica, Chinese Academy of Sciences, has shown that amygdala kappa-opioid receptor-dependent upregulation of glutamate transporter 1 mediates depressive-like behaviors in mouse models of opiate abstinence.
RSS
