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BioWorld - Saturday, June 14, 2025
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Heart, DNA and ECG

Nuevocor draws $45M series B for gene therapy in rare heart disease

May 6, 2025
By Nuala Moran
No Comments
Nuevocor Pte. Ltd. has closed a $45 million series B, enabling it to move lead gene therapy NVC-001 into the clinic in the treatment of an inherited form of cardiomyopathy.
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AI generated, 3D rendering of protein degradation
Cancer

AACR 2025: Induced proximity strategy, beyond degraders

May 2, 2025
By Anette Breindl
No Comments
Targeted protein degradation has yet to notch its first approval. But with more than two dozen agents now in clinical trials, the strategy’s ultimate clinical validation appears to be a matter of time.
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AACR 2025: Nouscom reports early but promising response in Lynch syndrome

April 29, 2025
By Nuala Moran
No Comments
Off-the-shelf cancer vaccine specialist Nouscom AG announced positive final results for its lead product, Nous-209, showing there was a “highly potent” and durable immune response in carriers of Lynch syndrome, a common hereditary condition that can increase the lifetime risk of cancer by as much as 80%. The data, presented at the annual American Association for Cancer Research meeting on April 29, indicate Nous-209 elicits a cancer-preventing effect.
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Drug vials and syringe

Vaccine Integrity Project launched to tackle ‘unfortunate reality’

April 25, 2025
By Nuala Moran
Nervousness about the Trump administration’s attitude to vaccines has spurred the formation of the Vaccine Integrity Project, which has the aim of safeguarding the use of vaccines and ensuring vaccine policy “remains grounded in the best available science,” and is “free from external influence.”
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Illustration of cancer tumor on pancreas
Cancer

PIKfyve enzyme is target to ‘starve’ pancreatic cancer cells

April 25, 2025
By Mar de Miguel
A metabolic vulnerability of pancreatic ductal adenocarcinoma (PDAC) could be used to address this type of cancer that often resists treatments. Scientists at the University of Michigan have discovered that inhibiting the PIKfyve enzyme prevented tumor development and reduced tumor growth by altering the lipid synthesis these cells rely on. The KRAS-MAPK pathway is involved in this process, leading the researchers to suggest that dual inhibitors of PIKfyve and KRAS-MAPK could be an effective therapeutic strategy.
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Harvard University Widener Library

Harvard fighting back with lawsuit against Trump administration

April 23, 2025
By Nuala Moran
Harvard University has filed a lawsuit claiming the Trump administration’s freezing of its federal funding is unlawful and beyond the government’s authority. Announcing the move, Harvard’s president, Alan Garber, highlighted the impact of freezing $2.2 billion in grants – and the threat to freeze a further $1.1 billion – will have on the university’s biomedical research.
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Gavel and scales
Policy

Harvard fighting back with lawsuit against Trump administration

April 23, 2025
By Nuala Moran
Harvard University has filed a lawsuit claiming the Trump administration’s freezing of its federal funding is unlawful and beyond the government’s authority. Announcing the move, Harvard’s president, Alan Garber, highlighted the impact of freezing $2.2 billion in grants – and the threat to freeze a further $1.1 billion – will have on the university’s biomedical research.
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Harvard fighting back with lawsuit against Trump administration

April 22, 2025
By Nuala Moran
Harvard University has filed a lawsuit claiming the Trump administration’s freezing of its federal funding is unlawful and beyond the government’s authority. Announcing the move, Harvard’s president, Alan Garber, highlighted the impact of freezing $2.2 billion in grants – and the threat to freeze a further $1.1 billion – will have on the university’s biomedical research.
Read More
Illustration of human brain and dna
Neurology/psychiatric

Commander proteins linked to lysosomal dysfunction in Parkinson’s

April 22, 2025
By Mar de Miguel
Genes associated with lysosomal dysfunction increase the risk of Parkinson’s disease (PD), according to a study led by scientists at Northwestern University. The discovery also explains why some people who carry a pathogenic variant of the GBA1 gene develop PD or dementia with Lewy bodies (DLB) and others do not. The key lies in the Commander complex, involved in the transport of proteins to this organelle. This discovery raises the need for combinatorial therapies that act on more than one pathway for this type of neurodegenerative disorder.
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DNA double helix with sand hour glass

M42 enters R&D with investment in longevity firm Juvenescence

April 16, 2025
By Nuala Moran
The Abu Dhabi health care company M42 is to make an investment in U.K.-based longevity specialist Juvenescence as a route to moving into drug discovery and development, with the two forming a partnership to work together on products that extend the healthy lifespan and improve the treatment of chronic diseases.
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