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BioWorld - Tuesday, May 24, 2022
Home » Topics » Science

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Multiple sclerosis

Study finds targets of T-cell response in multiple sclerosis

April 28, 2022
By Anette Breindl
No Comments
Screening a panel of potential autoantigens, investigators at the Karolinska Institute have identified four autoantigens that are targeted by the T cells of multiple sclerosis patients.
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Antibiotic resistant bacteria inside a biofilm,

ECCMID 2022: In antibiotic development, scientific ingenuity meets a dysfunctional marketplace

April 26, 2022
By Anette Breindl
No Comments
Antibiotics drugs discovery, Ursula Theuretzbacher told the audience at the 2022 European Congress of Clinical Microbiology & Infectious Diseases (ECCMID), has more than one challenge to overcome.
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Gene editing illustration

Researchers develop gene-editing platform to edit mitochondrial DNA

April 26, 2022
By Tamra Sami
No Comments
Researchers from the Center for Genome Engineering within South Korea's Institute for Basic Science have developed a new gene-editing platform that could be the final missing piece of the puzzle in gene-editing technology, by making editing of mitochondrial DNA possible.
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Human anatomy

Sex disparities of lupus recapitulated in mouse model

April 25, 2022
By Anette Breindl
No Comments
A new animal model of systemic lupus erythematosus (lupus) could be useful for understanding the disparity of the disorder, which is vastly more common in women than men.
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Cross section of brain

Deep brain stimulation of central thalamus restores consciousness in primate models

April 22, 2022
By Bernard Banga
No Comments
A research team led by neuroscientists and neurosurgeons from Paris-Saclay University have recently managed to demonstrate that electrical stimulation of the thalamus can restore consciousness when this has been impaired.
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Brain and neural networks

Post viral infection, resting T-cell subtypes cooperate to drive neuroinflammation

April 22, 2022
By Subhasree Nag
No Comments

Researchers led by Doron Merkler from the University of Geneva have shown how post local infection, a fraction of resting CD8+ tissue resident memory cells cross-reacted with antigens of the CNS to become subsequently activated and drive immunopathological responses in the CNS.


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Stroke illustration: brain, artery, neurons

Astrocyte-produced enzyme affects neuronal activity, stroke outcomes

April 21, 2022
By Anette Breindl
No Comments
By altering the balance between neuronal excitation and inhibition, researchers have reduced cell death and improved outcomes in animal models of stroke.
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CAR T cell attacking cancer cells

Testing viruses, vaccines, to increase solid tumor CAR T persistence

April 20, 2022
By Anette Breindl
No Comments
Solid tumors have been a tougher nut to crack for CAR T cells than B-cell cancers, for two main reasons. Solid tumors have an inhibitors microenvironment that has made it difficult to get durable responses. And identifying antigens as specific as the B-cell markers CD19 and CD22 has been challenging, leading to problems with on-target, off-tumor toxicity.
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Vega system

Vega 3-mouse ultrasound scan may accelerate preclinical drug development studies

April 19, 2022
By David Godkin
No Comments
Perkinelmer Inc. said the Vega is a first-of-its-kind preclinical ultrasound system that will accelerate preclinical research and drug development studies of cancer, cardiovascular, liver, kidney and other diseases. The imaging platform combines hands-free automation with high-throughput capability, which the company said is a major advance over manual ultrasound scanning across the bodies of individual lab mice.
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Tape measure, apple on scale

Microbe-sensing mechanism via neuronal Nod2 regulates appetite and metabolism

April 19, 2022
By Nuala Moran
No Comments
Microbiota are recognized as key regulators of the gut-brain axis, but whether brain neurons can directly sense bacterial components, and conversely, if bacteria are involved in modulating physiological processes via the brain, has not been demonstrated. Researchers at the Institute Pasteur in Paris have now shown that muropeptides directly inhibit the activity of neurons in the hypothalamus to regulate appetite, nesting behavior and body temperature in mice.
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