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BioWorld - Friday, May 23, 2025
Home » Topics » Science

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DNA, RNA concept art.

Genomic study paves way for multimorbidity treatments

Feb. 7, 2025
By Nuala Moran
A large-scale study cross-referencing genomic data from multiple sources with primary care health records has identified genetic overlaps in 72 chronic diseases, opening the way for a more holistic approach to researching, treating and preventing multimorbidity.
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Cancer cell, DNA illustration

Targeting translation could be novel way to fight Myc, other oncogenes

Feb. 5, 2025
By Anette Breindl
Researchers at the University of California at San Francisco have identified an RNA-binding protein that increased the translation of Myc mRNA. The authors wrote that their work, which was published online in Nature Cell Biology on Feb. 4, 2025, “transforms the understanding of the translational code in cancer and illuminates therapeutic openings to target the expression of oncogenes.”
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Photo of bird, H5N1 virus
Infection

Antibody prevents severe bird flu in macaques

Feb. 3, 2025
By Mar de Miguel
Scientists at the University of Pittsburgh have tested a broadly neutralizing antibody that binds the stem of a protein against H5N1 avian influenza, which prevented severe disease in nonhuman primates and was effective for at least 8 weeks. The scientists remark on the potential of the design developed by Astrazeneca plc against a possible outbreak of the influenza A virus.
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Immune cells (red) migrate to the pancreas and stimulate glucagon-producing cells (orange)
Endocrine/metabolic

Neurons send immune cells to the pancreas to regulate glucose

Jan. 30, 2025
By Mar de Miguel
The liver and pancreas are the main actors in glucose metabolism, but not the only ones. Muscles, adipose tissue and the brain play different roles. However, the prize for the best new actor in glucagon production goes to the innate lymphoid cells (ILCs), which, according to a study published in Science, respond to intestine neuron signals traveling to the pancreas to control glucose.
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Heart patch produced from induced pluripotent stem cells derived heart muscle cells in a collagen hydrogel

For the 99%, allografts can patch up failing heart

Jan. 29, 2025
By Anette Breindl
Implanted patches of iPS-derived heart muscle integrated with heart tissue in a primate model of heart failure, and in patients being treated in a clinical trial, marks progress toward a potential option for patients with advanced heart failure.
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Immune cells (red) migrate to the pancreas and stimulate glucagon-producing cells (orange)
Endocrine/metabolic

Neurons send immune cells to the pancreas to regulate glucose

Jan. 27, 2025
By Mar de Miguel
The liver and pancreas are the main actors in glucose metabolism, but not the only ones. Muscles, adipose tissue and the brain play different roles. However, the prize for the best new actor in glucagon production goes to the innate lymphoid cells (ILCs), which, according to a study published in Science, respond to intestine neuron signals traveling to the pancreas to control glucose.
Read More
Illustration of cobra in front of protein structures

An antidote to cobra venom designed with AI

Jan. 22, 2025
By Mar de Miguel
Following Nobel Prize-winning chemist David Baker’s recipe for cooking an antidote to cobra venom using artificial intelligence (AI) could be faster and more effective than currently available methods. The ingredients and steps can be found in a new study published by the University of Washington scientist in collaboration with the Technical University of Denmark. They are ready for the next steps in preclinical trials.
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Petri dishes

New drugs with the same old resistance tricks?

Jan. 21, 2025
By Coia Dulsat
According to the World Health Organization (WHO), multidrug-resistant pathogens caused over 1.27 million deaths worldwide in 2020. And figures are rising, with projections pointing to antimicrobial resistance surpassing cancer as the leading cause of death by 2050. Now, researchers at the HUN-REN Biological Research Center have unveiled the role of pre-existing genetic variabilities and specific cross-resistance patterns among several antibiotics designed to combat gram-positive bacteria.
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Petri dishes
Infection

New drugs with the same old resistance tricks?

Jan. 16, 2025
By Coia Dulsat
According to the World Health Organization (WHO), multidrug-resistant pathogens caused over 1.27 million deaths worldwide in 2020. And figures are rising, with projections pointing to antimicrobial resistance surpassing cancer as the leading cause of death by 2050. Now, researchers at the HUN-REN Biological Research Center have unveiled the role of pre-existing genetic variabilities and specific cross-resistance patterns among several antibiotics designed to combat gram-positive bacteria.
Read More
Tanycytes illuminated and color coded according to their depth in the hypothalamus brain of a mouse
Aging

Map is first step toward healthy brains into old age

Jan. 14, 2025
By Anette Breindl
2024 saw the completion of several cellular-resolution brain maps, including the entire fly brain and a comprehensive connections map of a cubic centimeter of human brain. 2025 began with the addition of another important map. In the Jan. 1, 2025, issue of Nature, researchers from the Allen Institute presented a map of areas and cell types where aging most affected the mouse brain.
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