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The art of war

By spying on quorum sensing, immune system picks its battles

Dec. 30, 2019
By Anette Breindl
In the Dec. 20, 2019, issue of Science, Stefan Kaufmann, who is the founding director of the Max Planck Institute for Infection Biology, and his colleagues report that the immune system could calibrate its response to Pseudomonas aeruginosa by monitoring the bacterial quorum sensing chatter.
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Bioworld MedTech’s Cardiology Extra for Dec. 30, 2019

Dec. 30, 2019
By Liz Hollis
Keeping you up to date on recent developments in cardiology.
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Bioworld MedTech’s Neurology Extra for Dec. 27, 2019

Dec. 27, 2019
By Andrea Applegate and Anette Breindl
Keeping you up to date on recent developments in neurology.
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Brain

Breaching all three meninges improves drug delivery to brain

Dec. 27, 2019
By Anette Breindl
A single injection of SOD1-targeting RNA into the subpial space, which is below the innermost meningeal layer, was able to spread throughout the spinal cord and, via retrograde delivery, into brain centers that project to the spinal cord in several animal models, including primates.
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Bacteria in petri dishes
The art of war?

By spying on quorum sensing, immune system picks its battles?

Dec. 27, 2019
By Anette Breindl
“Bacteria often only do harm at certain concentrations,” Stefan Kaufmann told BioWorld. In fact, bacteria have evolved an entire communication system, so-called quorum sensing, to monitor how many of their colleagues are in the vicinity, and then switch from growth to virulence only at high densities.? 
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Lungs

Bench Press for Dec. 27, 2019

Dec. 27, 2019
By Anette Breindl
Scientists at the University of Tuebingen have identified a network of antifibrotic RNAs, and showed that this network was controlled by the transcription factor Pparg. Fibrosis, which is essentially the formation of inappropriate scar tissue, contributes to multiple diseases, and its molecular mechanisms are poorly understood.
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Bioworld MedTech’s Oncology Extra for Dec. 24, 2019

Dec. 24, 2019
By Mark McCarty and Anette Breindl
Keeping you up to date on recent developments in oncology.
Read More
Brain
Spot on

Breaching all three meninges improves drug delivery to brain

Dec. 24, 2019
By Anette Breindl
A single injection of SOD1-targeting RNA into the subpial space, which is below the innermost meningeal layer, was able to spread throughout the spinal cord and, via retrograde delivery, into brain centers that project to the spinal cord in several animal models, including primates.
Read More
DNA illustration
APOE has secrets left

Large datasets, good statistics allow disease-agnostic SNP discoveries

Dec. 24, 2019
By Nuala Moran
LONDON – While large-scale biobanks that link genomics to longitudinal health records of diagnosis, treatment and outcomes promise to revolutionize the understanding of the genetics of complex disease, the detailed statistical analysis of those high-dimensional data is still very much in its infancy.
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Scientists report insights into the mechanics, literally, of IPF

Dec. 24, 2019
By John Fox
A Chinese study has established a previously unknown direct mechanistic link between elevated mechanical tension caused by impaired alveolar regeneration and progressive idiopathic pulmonary fibrosis (IPF), highlighting a pathogenic mechanism that may underlie fibrosis.
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