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BioWorld - Tuesday, December 23, 2025
Home » Topics » Clinical

Clinical
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Taiwan’s Senhwa advancing CK2 candidate against moderate COVID-19

Aug. 4, 2020
By Elise Mak
Senhwa Biosciences Inc., of Taipei, Taiwan, said casein kinase 2 (CK2) is the right target to aim at when developing a COVID-19 therapeutic treatment. The company’s silmitasertib is the only clinical-stage inhibitor of CK2, a kinase recently identified by researchers as being hijacked by SARS-CoV-2.
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Not sleepy or hollow, hopes for Legend high despite loss of head

Aug. 4, 2020
By Randy Osborne
With Glaxosmithkline plc (GSK) having sailed through an FDA advisory panel meeting July 14 centered on its belantamab mafodotin (belantamab), an antibody-drug conjugate (ADC) for multiple myeloma (MM), others in the B-cell maturation antigen (BCMA) space such as Legend Biotech Corp. are further piquing Wall Street’s interest.
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Antibodies fighting coronavirus

Celltrion doubles pace for COVID-19 antibody treatment CT-P59

Aug. 4, 2020
By Gina Lee
HONG KONG – Incheon, South Korea-based Celltrion Inc. is rapidly advancing CT-P59, its antiviral antibody treatment for the COVID-19 virus, after receiving its second green light to begin phase I trials.
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In the clinic for Aug. 4, 2020

Aug. 4, 2020
Clinical updates, including trial initiations, enrollment status and data readouts and publications: Angion, Arch, Avelas, Cellectar, Clene, Karuna, Keros, GT, Novartis, Oncopeptides, Regenxbio.
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Lilly goes onsite and three I-Spy giants collaborate for COVID-19 studies

Aug. 3, 2020
By Lee Landenberger
Since more than 40% of U.S. coronavirus deaths have links to U.S. long-term care facilities, Eli Lilly and Co. is getting on the road with a clinical trial design that takes researchers directly to outbreaks.
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DHODH enzyme makes catalyst grist for Immunic, others in MS-plus

Aug. 3, 2020
By Randy Osborne
Novartis AG didn’t say why the FDA has put off action until September – a delay of three months – on the sBLA for multiple sclerosis (MS) prospect Arzerra (ofatumumab, OMB-157), first cleared in October 2009 for chronic lymphocytic leukemia, but the holdup brought renewed attention to the bustling space, and Immunic Inc. – which held its R&D Day on May 27 – is coming on strong.
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Liver disease

Cymabay's seladelpar back on track, with pivotal PBC trial ahead

Aug. 3, 2020
By Michael Fitzhugh
Shares of Cymabay Therapeutics Inc. (NASAQ:CBAY) shot 37% higher on Monday after top-line data showed 78.2% of people with primary biliary cholangitis (PBC) in the company's disrupted phase III test of seladelpar achieved the primary composite outcome after just three months on a 10-mg dose of the drug vs. 12.5% in the trial’s placebo arm.
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In the clinic for Aug. 3, 2020

Aug. 3, 2020
Clinical updates, including trial initiations, enrollment status and data readouts and publications: Abbvie, Akebia, Amgen, Active, Aileron, Arcutis, Biohaven, Cymabay, Genmab, Immunic, Innovent, Janssen, Kadimastem, Lilly, Lipocine, Myokardia, Polyphor, Takeda.
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In the clinic for July 28, 2020

Aug. 3, 2020
Clinical updates, including trial initiations, enrollment status and data readouts and publications: Abbvie, American Brivision, Arch, Astrazeneca, Biontech, Bridgebio, Chiasma, Cleave, Corcept, Cue, Grifols, Interion, Mind, Miragen, Orion, Pfizer, Plus, Reata, Recordati, Redhill, Spectrum.
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Product image

Setpoint to start U.S. pivotal trial for RA implant around year end

July 31, 2020
By Stacy Lawrence
A bioelectronic platform that stimulates the vagus nerve to reduce inflammatory activity and restore balance in the immune system is the ultimate aim of Setpoint Medical Inc. The Valencia, Calif.-based startup is preparing to start a U.S. pivotal trial for its most advanced program in rheumatoid arthritis (RA) later this year or early next.
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