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BioWorld - Monday, January 30, 2023
Home » Topics » Diabetes, BioWorld

Diabetes, BioWorld
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Going public ticker

Structure files for first biopharma US IPO of year, aiming to raise up to $100M

Jan. 13, 2023
By Jennifer Boggs
No Comments
Leveraging a computational platform designed to exploit the full potential of a widely studied pharma target has proved successful in attracting venture investors in the last few years to Structure Therapeutics Inc. The company now is giving the public markets a go, aiming to raise up to $100 million in what marks the first biopharma U.S. IPO filing for 2023.
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Oral medication

Oramed quits oral insulin development in type 2 diabetes after phase III failure

Jan. 12, 2023
By Lee Landenberger
No Comments
Oramed Pharmaceuticals Inc. has had a lot of success with testing its oral insulin, until now. The company will discontinue it oral insulin clinical work in treating type 2 diabetes after ORMD-0801 failed to hit its phase III study’s primary and secondary endpoints. The late-stage stumble clobbered the company stock (NASDAQ:ORMP), which lost 76% of its value on Dec. 12 to close at $2.54 each.
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Hightide raises $107M series C to advance lead metabolic disease program to phase III

Jan. 6, 2023
By Tamra Sami
No Comments
Hightide Therapeutics Inc. closed a $107 million series C round that will advance multiple global development programs for lead candidate HTD-1801, including a phase III trial in type 2 diabetes.
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Diagram of of the main human adipose tissue depots in the body.
‘22 in review

As weight loss medicine advances, its relevance recedes

Dec. 30, 2022
By Anette Breindl
No Comments
Metabolic health is at an odd juncture. With the advent of glucagon-like peptide (GLP-1) agonists, pharmacologically induced weight loss has matured into a viable therapeutic option at long last. And research into the drug class is continuing apace.
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Adult checking child blood glucose level

FDA victory in hand, Tzield-bearer Provention goes to battle in type 1 diabetes

Nov. 18, 2022
By Randy Osborne
No Comments
Provention Bio Inc. scored approval from the U.S. FDA of the BLA for Tzield  (teplizumab-mzwv), an intravenously given, anti-CD3-directed antibody, as the first and only immunomodulatory treatment to delay the onset of stage 3 type 1 diabetes (T1D) in adult and pediatric patients ages 8 and older with stage 2 T1D.
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Oral medication

NMPA nod gives Hua Medicine first GKA approval in diabetes

Oct. 10, 2022
By Doris Yu
No Comments
Hua Medicine Ltd. has received marketing approval from China's NMPA for its glucokinase activator (GKA), Huatangning (dorzagliatin tablets), for two indications: as a monotherapy to improve blood glucose control for drug-naïve type 2 diabetes patients and in combination with metformin in metformin-tolerated type 2 diabetes patients to control blood glucose level. It marks the first GKA drug to gain approval in any market, according to Hua.
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Glass yen/yuan symbol

Huisheng raises ¥500M in series A round for diabetes drugs

Sep. 27, 2022
By Doris Yu
No Comments
Jilin Huisheng Biopharmaceutical Co. Ltd., a non-wholly owned subsidiary of Sihuan Pharmaceutical Holdings Group Ltd., has raised ¥500 million (US$70 million) in a series A round. Huisheng, which has developed a pipeline of programs addressing both diabetes and its complications, plans to use the new funds to speed up its clinical trials and purchase manufacturing equipment, according to Che Fengsheng, executive director and chairman of Sihuan Pharma.
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Bears at the WSU Bear Center.
Endocrine/Metabolic

Research identifies proteins that let sleeping bears lie

Sep. 22, 2022
By Anette Breindl
No Comments
Investigators at Washington State University (WSU) have identified a set of eight proteins that were expressed in the serum of Ursus arctos horribilis, better known as the grizzly bear, specifically during their hibernation period. In addition to reporting new basic insights into hibernation, the study, which was published in the Sept. 21, 2022, issue of iScience, could also give clues to insulin resistance and its relationship to body fat.
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Akston starts small and likes it that way

Sep. 7, 2022
By Lee Landenberger
No Comments
Akston Biosciences Corp. emerged from a successful small company that was sold to a pharma major. For Todd Zion, that’s a back-to-basics move that suits him just fine. Zion co-founded Smartcells Inc. in 2003 with technology developed at the Massachusetts Institute of Technology. The company went on to develop the once-daily injectable self-regulating insulin product, Smartinsulin, and sold it to Merck & Co. in what was at the time one of the largest preclinical pharmaceutical acquisitions ever.
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Tape measure, apple on scale

Clinically and preclinically, combinations boost incretin mimetics

Aug. 25, 2022
By Anette Breindl
No Comments
A phase II trial this week showed that combining the diabetes drug semaglutide (Novo Nordisk A/S) with a fixed-dose combination of Cagrisema (cagrilintide/semaglutide) led to “numerically higher” reductions in both HbA1c and body weight than either component alone. And on the preclinical side, researchers from the Novo Nordisk Research Center and the Helmholtz Diabetes Center reported that linking the dual PPAR activator tesaglitazar to GLP-1 improved glucose control in male mice. Both bits of news illustrate that GLP-1R agonists, which are also called incretin mimetics and GLP-1 analogs, are likely to continue their success across multiple areas of medical care.
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