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Home » Topics » Disease categories and therapies » Ear, nose and throat

Ear, nose and throat
Ear, nose and throat RSS Feed RSS

Hand cupping ear to illustration hearing loss
Ear, nose & throat

GJB2-GT has specific targeting and efficacy in preclinical models of deafness

March 12, 2025
Pathogenic variants in the GJB2 gene are the most common genetic cause of congenital sensorineural hearing loss and are mostly associated with an autosomal recessive non-syndromic deafness 1A (DFNB1A).
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Anatomical model of the ear next to an otoscope
Ear, nose & throat

New animal model of eosinophilic otitis media developed

March 10, 2025
Eosinophilic otitis media (EOM) is a type 2-related otitis media. Scientists at the Hirosaki University Graduate School of Medicine have developed a new EOM animal model in guinea pigs by using the plant protease papain. Papin was intratympanically administered in a daily basis. They also investigated the expression of innate lymphoid cell type 2 (ILC2) in the middle ear mucosa of these animals.
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Mouse genome/DNA sequencing concept art.
Genetic/congenital

Researchers develop novel Kabuki syndrome murine model

March 7, 2025
Lysine demethylase 6A (KDM6A) is a demethylase that plays a key role at regulating developmental gene expression signatures in several tissues, including neuronal cells. The KDM6A gene is located in chromosome X and pathogenic variants in this gene are tied to Kabuki syndrome type 2. Even though progress in understanding the functions of KDM6A has been made, its role in cochlear development and auditory function remains poorly understood.
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Illustration demonstrating parts of the ear
Ear, nose & throat

AC-102 penetrates rapidly, distributes evenly along the cochlea after intratympanic delivery in pigs

March 5, 2025
Researchers from Medical University of Vienna and affiliated organizations have presented findings from a study that aimed to assess the perilymph and tissue distribution of AC-102, a small and lipophilic intratympanically delivered pyridoindole derivative, in clinical development at Audiocure Pharma GmbH for the treatment of idiopathic sudden sensorineural hearing loss.
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Man holding hand up to ear
Ear, nose & throat

GABARAP emerges as a therapeutic target to prevent aminoglycoside-induced hearing loss

March 3, 2025
Aminoglycoside antibiotics are essential for treating some severe bacterial infections but are notorious for causing irreversible hearing loss in 20%-47% of patients.
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Hearing ear icon
Ear, nose and throat

NS-101 restores synapse function in hearing loss models

Feb. 28, 2025
Family with sequence similarity 19 member A5 (FAM19A5) is a secretory protein highly expressed in the brain that regulates synapse dynamics through its interaction with leucine-rich repeat-containing 4B (LRRC4B). Noise exposure is one of the most significant causes of synapse loss between inner hair cells and auditory nerve fibers, leading to a decline in hearing sensitivity.
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Ear, nose and throat

Restoring GJB2 expression rescues hereditary hearing loss

Feb. 26, 2025
The most common form of hereditary deafness in humans is caused by mutations in the GJB2 gene, which encodes the gap junction protein connexin 26. That regulates the transport of potassium and metabolites between inner ear cells. The coding sequence of this gene fits in an adenovirus-associated vector (AAV), making it an attractive approach for gene therapy.
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Child cupping hand to ear

Regeneron gene therapy improves children’s hearing

Feb. 25, 2025
By Lee Landenberger
In Regeneron Pharmaceuticals Inc.’s phase I/II Chord study of 12 children with genetic hearing loss, 10 out of 11 have shown improvements after being treated with a gene therapy. “What is really remarkable about this type of therapeutic approach is that the first people who are going to see the impact are not actually the physicians – it’s the families,” Jonathon Whitton, vice president and Regeneron’s auditory global program head, told BioWorld.
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Ear illustration

Loud and clear: Sound Pharma has phase III success in Meniere’s

Dec. 11, 2024
By Lee Landenberger
Sound Pharmaceuticals Inc.’s lead candidate, the anti-inflammatory SPI-1005 (ebselen), has produced positive pivotal phase III study data in treating Meniere’s disease, an inner-ear disorder that can lead to vertigo and deafness.
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RNA strand
Ear, nose & throat

Ribox’s RXRG-001 cleared to enter clinic for radiation-induced xerostomia and hyposalivation

Oct. 28, 2024
Ribox Therapeutics Ltd. has obtained IND clearance from the FDA for the company’s circular RNA therapy, RXRG-001.
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