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BioWorld - Friday, January 9, 2026
Home » Topics » Disease categories and therapies » Infection

Infection
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Infection

Japanese investigators describe new compounds for malaria

Dec. 16, 2022
Nagasaki University and Shionogi & Co. Ltd. have synthesized quinolone compounds reported to be useful for the treatment of malaria.
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Infection

Gilead Sciences discloses new compounds for Zika virus infection

Dec. 15, 2022
Gilead Sciences Inc. has presented tetracyclic compounds reported to be useful for the treatment of Zika virus infection.
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Lab glassware and scientist
Neurology/Psychiatric

Qrons to explore Tellurium-based compounds with QS-200 for concussion, infection and sepsis

Dec. 15, 2022
Qrons Inc. has established a collaboration with scientists at a public research university in Israel, by which Tellurium-based compounds in combination with Qrons' QS-200 product candidate and other configurations will be explored as treatment for diffused axonal injuries (concussions), which accounts for approximately 89% of traumatic brain injuries (TBIs).
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Colorized transmission electron micrograph of rabies virus.
Infection

Everest achieves preclinical proof-of-concept milestone for its mRNA rabies vaccine

Dec. 15, 2022
Everest Medicines Ltd. has achieved a preclinical proof-of-concept milestone for its mRNA rabies vaccine program. This new vaccine candidate for rabies post-exposure prophylaxis was developed in partnership with Providence Therapeutics Holdings Inc. utilizing a clinically validated mRNA technology platform.
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Illustration of infected kidneys, ureter and bladder
Infection

Biomaterial-based sublingual vaccine shows prolonged preclinical efficacy in preventing UTIs

Dec. 15, 2022
Currently, most patients with urinary tract infections (UTIs) require long-term antibiotic treatment, which poses risks of resistance development and alters the patients' microbiota. Therefore, vaccines that raise safe, effective and long-lasting immune responses across populations for UTI prevention constitute a critical medical need. However, developing such vaccination strategies remains challenging because the responses need to be specific to a broad range of UTI-causing bacteria and include both blood and mucosal responses in the urogenital tract.
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US FDA starts afresh with TB drug guidance

Dec. 14, 2022
By Mari Serebrov
Given all the advances that have been made over the past decade, the U.S. FDA decided to issue a new draft guidance on developing antibacterial drugs to treat pulmonary tuberculosis (TB) rather than finalize the draft it issued in 2013. In releasing the new draft, the agency cited advancements made in nonclinical models, streamlined clinical development programs and growing interest in treatment-shortening combination regimens.
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Infection

Drugs for Neglected Diseases Initiative identifies new compounds for leishmaniasis

Dec. 14, 2022
Drugs for Neglected Diseases Initiative has described pyrrolopirimidine derivatives reported to be useful for the treatment of leishmaniasis.
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Infection

Gilead Sciences identifies new compounds for Zika virus infection

Dec. 13, 2022
Gilead Sciences Inc. has presented pentacyclic derivative compounds reported to be useful for the treatment of Zika virus infection.
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Infection

Japanese researchers patent new viral 3CLpro inhibitors

Dec. 13, 2022
The National Center for Global Health and Medicine (NCGM) and Tokyo Medical and Dental University have divulged 3C-like protease (3CLpro) (SARS-CoV-2) inhibitors reported to be useful for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections (COVID-19).
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3D renderings of RSV
Infection

Antibody effector functions predict protection against RSV re-infection

Dec. 13, 2022
By Helen Albert
Both neutralizing antibodies and antibody effector functions are needed for protection against re-infection with respiratory syncytial virus (RSV), which may explain why it has been challenging to design an effective vaccine against the virus. As reported in the Dec. 12, 2022, issue of Cell, researchers carried out a human challenge study where volunteers were given a candidate vaccine for RSV, Ad26, or placebo.
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