Delix Therapeutics Inc. has identified pyrrolidine psychoplastogens acting as 5-HT2A receptor modulators reported to be useful for the treatment of neurodegeneration, substance abuse and dependence, impulse control, mood, sleep, anxiety, eating and personality disorders, among others.

Whanin Pharmaceutical Co. Ltd. has disclosed macrocyclic pyrimidine derivatives acting as...

Novartis AG has described pyridine-3-carboxylate compounds acting as voltage-dependent L-type calcium channel subunit α-1C channel (Cav1.2) activators reported to be useful for the treatment of schizophrenia, major depression, attention deficit hyperactivity disorder, autism spectrum disorder, multiple sclerosis, frontotemporal dementia, Alzheimer’s disease and Brugada syndrome.

IRBM SpA, Rainwater Charitable Foundation and...

Evidence of mitochondrial and lysosome dysfunction underlying Parkinson’s disease (PD) was discussed during several talks at the World Parkinson Congress 2023 (WPC) held in Barcelona. Edward A. Fon, from McGill University in Montreal, explained how eyes turned to mitochondria as key players in PD more than 30 years ago and how the explosion of genetics was fundamental to advance the knowledge and research in PD.

Nodthera Ltd. claims to be first to demonstrate it is possible to modulate the NLRP3 inflammasome in the brain, after showing there were reductions in inflammatory and disease-specific biomarkers in blood and cerebrospinal fluid after seven days of daily administration of its lead product, NT-0796, an oral NLRP3 inhibitor.