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BioWorld - Wednesday, December 24, 2025
Home » Topics » Drugs » Bispecific antibody

Bispecific antibody
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The year in review

Big pharma taps fast Asia innovation in search of next Keytruda

Dec. 23, 2025
By Marian (YoonJee) Chu
No Comments
Speed and innovation from Asia Pacific’s (APAC) biotechnology sector had big pharma scouring the region for the next oncology heir to Keytruda (pembrolizumab), Merck & Co. Inc.’s reigning blockbuster cancer drug.
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Immuno-oncology

Crossbow Therapeutics highlights activity of TERT-targeting CBX-663

Dec. 23, 2025
No Comments
Crossbow Therapeutics Inc. has provided details on the preclinical characterization for the telomerase reverse transcriptase (TERT)-targeting T-cell engager CBX-663.
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Cancer

Disco closes €36M seed round to advance surfaceome technology

Dec. 12, 2025
By Nuala Moran
No Comments
Disco Pharmaceuticals GmbH announced the final close of its seed round at €36 million (US$42 million), as it shapes up novel targets it has discovered with its surfaceome platform technology for formal preclinical development.
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Illustration of T cells attacking tumor

Disco closes €36M seed round to advance surfaceome technology

Dec. 11, 2025
By Nuala Moran
No Comments
Disco Pharmaceuticals GmbH announced the final close of its seed round at €36 million (US$42 million), as it shapes up novel targets it has discovered with its surfaceome platform technology for formal preclinical development.
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Aimedbio IPO

Aimedbio debuts with $48M Kosdaq IPO

Dec. 9, 2025
By Marian (YoonJee) Chu
No Comments
Aimedbio Inc. raised ₩70.73 billion (US$48.24 million) in its Dec. 4 IPO, marking the largest Kosdaq listing this year.
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Green and red bispecific antibodies

Crescent, Kelun in two-way deal, including PD-1/VEGF bispecific

Dec. 9, 2025
By Marian (YoonJee) Chu
No Comments
Crescent Biopharma Inc. teamed with Sichuan Kelun-Biotech Biopharmaceutical Co. Ltd. to generate “parallel” data of its PD-1/VEGF bispecific antibody, CR-001. The goal is to get 2027 readouts of the bispecific as a monotherapy and as a combination therapy with antibody-drug conjugates in both the U.S. and China.
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Multiple myeloma illustration

ASH 2025: Tec-dara shines on ‘functional cure’ Majestec-3 MM data

Dec. 9, 2025
By Karen Carey
Impressive results of a potential second-line combination treatment for multiple myeloma from the Majestec-3 trial of teclistamab plus daratumumab raised eyebrows at the American Society of Hematology’s 67th annual meeting, with the combination showing an 83.4% rate of progression-free survival at three years vs. 29.7% for standard of care.
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Green and red bispecific antibodies

Crescent, Kelun in two-way deal, including PD-1/VEGF bispecific

Dec. 5, 2025
By Marian (YoonJee) Chu
No Comments
Crescent Biopharma Inc. teamed with Sichuan Kelun-Biotech Biopharmaceutical Co. Ltd. to generate “parallel” data of its PD-1/VEGF bispecific antibody, CR-001. The goal is to get 2027 readouts of the bispecific as a monotherapy and as a combination therapy with antibody-drug conjugates in both the U.S. and China.
Read More
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Immuno-oncology

Laigo raises €11.5M seed money for targeted protein degradation

Dec. 5, 2025
By Nuala Moran
No Comments
Laigo Bio BV has raised €11.5 million (US$13.7 million) in a seed round for the further development of a new approach to inducing targeted protein degradation by E3 ubiquitin ligases.
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Cancer

CR-001, a PD-1 x VEGF bispecific antibody with potent activity

Dec. 5, 2025
No Comments
Researchers from Crescent Biopharma Inc. and Paragon Therapeutics Inc. presented the preclinical development of CR-001.
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