Tumor cells are known to produce high amounts of intracellular lipids, leading to increased levels of fatty acids, cholesterol and membrane phospholipids. Death domain-associated protein (DAXX) is a small ubiquitin-related modifier (SUMO)-binding protein that plays a role in transcription regulation by interacting with transcription factors such as p53 and NF-κB.

Acid sphingomyelinase (ASM) is a sphingolipid metabolizing enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide. Previous studies revealed high activity of ASM in the blood and brain of old vs. young individuals or mice, and they implicated this enzyme in neurodegenerative disease pathology.

Excessive cytotoxic lipofuscin bisretinoid accumulation in the eye is thought to be among the main causes behind the pathogenesis of...

Researchers from Georgia State University presented the discovery and preclinical evaluation of novel antiviral candidates against the SARS...

Blue Water Vaccines Inc. (BWV) has signed a sponsored research agreement with the University of Texas (UT) Health Science Center at San...

The most comprehensive study to date of how lung cancer evolves in response to selection pressures indicates the genetic profile at diagnosis can be used to predict how a tumor is likely to progress, opening up new prospects for personalized medicine and potential therapeutic targets. The data were generated in Tracerx (Tracking cancer evolution through therapy), a £14 million (US$17.4 million) study funded by the charity Cancer Research UK (CRUK) with the aim of defining how clonal heterogeneity of tumor cells affects the risk of recurrence and survival.