Bone development is a continuous process, but in some cases, soft tissues can mineralize due to some anomalies in repairing processes, thus leading to heterotopic ossification (HO). Max Planck Institute for Molecular Genetics researchers aimed to find the genetic causes tied to this abnormal bone-formation disorder.
Researchers from University of Belgrade, St. Jude Children’s Research Hospital and affiliated organizations have provided details on the discovery of novel orally bioavailable BET inhibitors as potential anticancer drug candidates.
Researchers at Cold Spring Harbor Laboratory have successfully reversed epigenetic changes and slowed tumor growth in mouse models of diffuse intrinsic pontine glioma (DIPG) using antisense oligonucleotide (ASO) technology. DIPG is a rare pediatric brain cancer where the tumor’s location in the pons of the brainstem makes surgery impossible, and fractioned radiotherapy and chemotherapy efforts have failed to improve survival so far.
Researchers have gained new insights into physiological mechanisms that protect against blood clotting in immobilized individuals by studying animals that stay immobile for a good chunk of the year at a time: hibernating bears. “As a clinician, if you think about immobility, you always think about thrombosis,” Tobias Petzold told BioWorld. But his team’s work, which was published in the April 13, 2023, issue of Science, demonstrated that “immobility can trigger antithrombotic mechanisms.”
Lomond Therapeutics Inc. has prepared and tested compounds having N-arylpyrimidin-2-amine derivatives and acting as protein kinase inhibitors, particularly mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1; HPK1; MEKKK1). As such, they are reported to be useful for the treatment of autoimmune diseases, sepsis, neurodegeneration, male infertility, vascular and inflammatory disorders, cancer and viral infections.
Clevudine derivatives and its phosphoramidates have been detailed in an Emory University patent as potentially useful for the treatment of hepatitis B virus (HBV) infection.
Long Island University and Mount Sinai School of Medicine have jointly developed intermediate conductance KCa3.1 (IKCa1) channel blockers reported to be useful for the treatment of renal disorders.
Recent Vanderbilt University patents describe metabotropic glutamate mGlu5 receptor negative allosteric modulators reported to be useful for the treatment of amyotrophic lateral sclerosis, Angelman syndrome, anxiety disorder, autism spectrum disorders, substance abuse and dependence, Alzheimer’s disease, diabetes and obesity, among others.
Studies in animal models and humans have identified an important role for peripheral chemoreceptors in the pathogenesis of heart failure. Thus, inhibiting their hyperactivity has been proposed as a potential therapeutic strategy for this major public health problem.
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