Genascence Corp. has been awarded US$11.6 million over 4 years from the California Institute for Regenerative Medicine (CIRM) to help advance the company's GNSC-001 gene therapy for knee osteoarthritis (OA). The funding will support a phase Ib trial and manufacturing activities.
Researchers at F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. have described haloacethydrazide compounds acting as legumain (asparaginyl endopeptidase; LGMN; AEP) inhibitors reported to be useful for the treatment of subacute sclerosing panencephalitis, progressive supranuclear palsy, frontotemporal dementia and Alzheimer's disease, among others.
Shanghai Litedd Co. Ltd. has divulged 8-oxo-3-azabicyclo[3.2.1]octane compounds acting as ATR kinase inhibitors reported to be useful for the treatment of cancer.
Adlai Nortye Pharmaceutical Co. Ltd. has identified Wnt signaling inhibitors reported to be useful for the treatment of cancer, immunological and inflammatory disorders.
Medshine Discovery Inc. has synthesized macrocyclic compounds acting as HIV integrase inhibitors reported to be useful for the treatment of HIV infections.
Louisiana State University has disclosed 5-HT2 receptor ligands reported to be useful for the treatment of anxiety, depression, asthma, chronic obstructive pulmonary disease (COPD), Alzheimer's disease, rheumatoid arthritis, chronic pain and post-stress traumatic disorder, among others.
Coronary artery disease (CAD) will likely remain the worldwide leading cause of death for the next couple of decades. Genome-wide association studies (GWAS) have been useful to identify hundreds of genomic loci that contribute CAD risk.
Bioatla Inc. has received FDA clearance of its IND application to evaluate BA-3182, a conditionally active biologic (CAB) EpCAM/CD3 bispecific T-cell engager antibody, for the treatment of advanced adenocarcinoma. The company plans to initiate a phase I study this year.
Researchers from Suzhou Alphama Biotechnology Co. Ltd. have reported the discovery of a novel selective KRAS G12C inhibitor, 143D, as a potential new anticancer drug.
Researchers from PDS Biotechnology Corp. and affiliated organizations have detailed the development and preclinical evaluation of recombinant protein vaccines formulated with enantio-specific cationic lipid R-DOTAP.
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