Suzhou Zion Pharma Technology Co. Ltd. has divulged serine-protein kinase ATM (ataxia telangiectasia mutated) inhibitors reported to be useful for the treatment of cancer.
Chiesi Farmaceutici SpA has synthesized Janus kinase inhibitors, particularly JAK1, JAK2, JAK3 and nonreceptor tyrosine-protein kinase TYK2 inhibitors, reported to be useful for the treatment of asthma, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis and acute respiratory distress syndrome.
Medshine Discovery Inc. has presented furan fused ring-substituted glutarimides as proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase-binding moiety covalently linked to androgen receptor-targeting moiety reported to be useful for the treatment of prostate cancer.
Shenzhen Forward Pharmaceutical Co. Ltd. has divulged estrogen receptor α (ERα) antagonists and/or degradation inducers reported to be useful for the treatment of cancer.
Allorion Therapeutics Co. Ltd. has patented nonreceptor tyrosine-protein kinase TYK2 inhibitors reported to be useful for the treatment of psoriasis, inflammatory bowel disease, psoriatic arthritis, ulcerative colitis, Crohn's disease and systemic lupus erythematosus.
It is largely known that oral drug delivery for macromolecules is often limited by the degradative environment of the gastrointestinal tract. Researchers from the Massachusetts Institute of Technology and their collaborators have presented Robocap, an oral mucus-clearing drug-delivery capsule that enhances the gastrointestinal absorption of drugs.
Extracellular vesicles (EVs) are nanosized membrane vesicles released from a variety of cells that play important roles in cell-cell communication and which circulate in almost every body fluid, including blood, urine and cerebrospinal fluid (CSF).
Primary ovarian insufficiency (POI) is a clinical syndrome characterized by premature exhaustion of the resting pool of primordial follicles before the age of 40 years in women; the mechanism of follicular depletion is not well understood.
It has been previously demonstrated that prepulse inhibition (PPI) is modulated by neurosteroids and in vivo research in mice has shown that PPI of the startle, a well-validated index of sensorimotor gating, is reduced by the neurosteroid allopregnanolone (AP). In recent work, a group of international researchers aimed to assess whether AP might mediate the PPI-disrupting effects of acute stress.
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