A multiomic analysis of the HIV reservoir has characterized the phenotypic and epigenetic heterogenicity of the virus-infected memory CD4+ T-cell population in people living with HIV taking antiretroviral therapy (ART-PLWH). This is the step towards an ex vivo single-cell atlas for these cells, which could help to design new strategies to eliminate the reservoir.
Jiangsu Chia Tai Tianqing Pharmaceutical Group Co. Ltd. has described proteolysis targeting chimeras (PROTACs) comprising of E3 ubiquitin ligase cereblon (CRBN) binding moiety covalently linked to a Bruton tyrosine kinase (BTK) binding moiety through a linker. They are reported to be useful for the treatment of cancer, inflammatory and autoimmune diseases.
Vertex Pharmaceuticals Inc. has divulged N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides acting as sodium channel protein type 10 subunit α (SCN10A; Nav1.8) blockers reported to be useful for the treatment of pain, arrhythmia, Charcot-Marie-Tooth disease, cough, urinary incontinence and multiple sclerosis.
Jiangsu Hengrui Medicine Co. Ltd. and Shanghai Senhui Pharmaceutical Co. Ltd. have identified pyridine compounds acting as HIV integrase inhibitors reported to be useful for the treatment of HIV infections.
Council of Scientific and Industrial Research (India) has synthesized substituted tricyclic heterocyclic compounds acting as β-lactamase IMP-1 (bacterial) and/or New Delhi metallo-β-lactamase-1 (NDM-1) (bacterial) inhibitors reported to be useful for the treatment of bacterial infections.
Genentech Inc. has disclosed 2,8-diazaspiro [4.5] decane compounds acting as serine/threonine-protein kinase LATS1 and/or LATS2 inhibitors reported to be useful for the treatment of acute respiratory distress syndrome (ARDS).
The most common cause of anemia in chronically ill hospitalized patients is due to inflammatory anemia (IA) that is caused indirectly by diseases such as autoimmune, cancer, chronic kidney disease, congestive heart failure, or pulmonary disease. The precise and common etiology of these diseases involves hypercytokinemia that leads to excessive increases in hepcidin, a master regulator of iron homeostasis that blocks intestinal iron absorption when levels are too persistently high.
Non-Hodgkin lymphomas (NHLs) originate from a clonal expansion of B cells (85%), T cells/NK cells (15%) or macrophages (~1%) due to an accumulation of genetic lesions in tumor suppressor genes. Approximately 82,000 new cases of NHL were diagnosed in 2021.
Oncoprotein Myc is known to be dysregulated in about 70% of cancers, and it is highly expressed in leukemias and lymphomas. Targeting Myc has not been successful and is still an unmet clinical need for cancer patients.
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