Frontier Medicines Corp. has selected its first development candidate, FMC-376, an oral, covalent small-molecule inhibitor that selectively targets both active (GTP-bound) and inactive (GDP-bound) conformations of KRAS G12C.
The sigma 1 receptor is widely distributed in the nervous system and its function has been implicated in a number of neurological disorders including dementia, Alzheimer’s disease (AD) and other neurodegenerative diseases. In a recent publication, researchers from the University of Nebraska detailed the discovery of novel sigma 1 receptor modulators.
Researchers at the University of Cape Town have compared the T-cell responses of individuals who were infected with Mycobacterium tuberculosis but were able to control the infection to those who developed active disease. The researchers wrote that the shared antigens in controllers “can be considered as high-priority targets for future vaccine development.” Their results were published online in Nature Medicine on Jan. 5, 2023. In their experiments, the team first sequenced the CDR3β region of the T-cell repertoire in a total of 166 individuals with M. tuberculosis infection who progressed to either TB or controlled infection.
Tencent Technology (Shenzhen) Co. Ltd. has disclosed pyrrolo[2,1-f][1,2,4]triazine derivatives acting as dual specificity protein kinase TTK inhibitors reported to be useful for the treatment of cancer.
Metacen Therapeutics Corp. has synthesized compounds able to capture methylglyoxal (MGO) reported to be useful for the treatment of aging, diabetes, hyperlipidemia, neurodegeneration, autism spectrum disorder, nonalcoholic fatty liver disease (NAFLD), fibrosis and cardiovascular disorders.
Johns Hopkins University has described prodrugs of sphingomyelin phosphodiesterase 3 (SMPD3; nSMase2) inhibitors reported to be useful for the treatment of cancer, neurological disorders, infections and inflammatory disorders.
Shanghai Raising Pharmaceutical Co. Ltd. has disclosed pyrimidines acting as amyloid-β (Aβ) protein production inhibitors reported to be useful for the treatment of Alzheimer's disease.
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