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BioWorld - Friday, April 3, 2026
Breaking News: Best of BioWorld Science: Q1Breaking News: Best of BioWorld Science: Q1Breaking News: Best of BioWorld Science: Q1
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Illustration of family and microbes.
Infection

Vedanta awarded new funding from CARB-X to advance VE-707

May 2, 2024
Vedanta Biosciences Inc. has been awarded $3.9 million in funding from the Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator (CARB-X) to advance its VE-707 preclinical development program for reducing colonization and preventing subsequent infections caused by multidrug-resistant organisms (MRDOs).
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Aspergillus mold
Infection

Antifungal SCY-247 shows efficacy against Candida and Aspergillus

May 2, 2024
Current approved antifungal therapies are limited by their associated adverse events. SCY-247 is a new triterpenoid antifungal for intravenous or oral administration that inhibits the glucan synthase enzyme, which is a key member for the fungal cell wall.
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Cancer

New TLR2/1 agonist induces pyroptosis in cancer cells

May 2, 2024
Researchers from the Beijing Institute of Radiation Medicine have presented the discovery of novel toll-like receptor (TLR)2/1 agonists as potential candidates for the treatment of lung cancer.
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Blood cell, test tubes, dropper
Hematologic

Gut microbe enzymes can produce universal donor blood cells

May 2, 2024
By Nuala Moran
Researchers have identified enzymes in gut microorganisms that could cleave A and B antigens from red blood, transmuting them to O negative cells. This is “a decisive step forward” in the quest to develop a universal donor blood that can be administered to people of any blood group without eliciting a harmful immune response, according to Maher Abou Hachem of the Technical University of Denmark, who co-led the research.
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Other news to note for April 30, 2024

April 30, 2024
Additional early-stage research and drug discovery news in brief, from: Alterity Therapeutics, Hyundai Bioscience.
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Holiday notice

April 30, 2024
In accordance with the publishing schedule, BioWorld Science will not be published on Wednesday, May 1, 2024.
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Cancer

Jaguahr Therapeutics reports new AhR antagonists for treatment of cancer

April 30, 2024
A Jaguahr Therapeutics Pte Ltd. patent describes new aryl hydrocarbon receptor (AhR) antagonists reported to be useful for the treatment of cancer.
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Ocular

cGAS inhibitors described in Bellbrook Labs patent

April 30, 2024
Work at Bellbrook Labs LLC has led to the discovery of imidazolyl-alkoxyquinolin-2-amines acting as cyclic GMP-AMP synthase (MB21D1; cGAS) inhibitors.
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Cancer

Hotspot Therapeutics patents CBL-B inhibitors

April 30, 2024
Hotspot Therapeutics Inc. has identified new E3 ubiquitin-protein ligase CBL-B inhibitors reported to be useful for the treatment of cancer.
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Infection

Bluejay Therapeutics identifies new compounds for bacterial and viral infections

April 30, 2024
New indazole pyridone compounds and their prodrugs have been patented by Bluejay Therapeutics Inc.
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