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BioWorld - Wednesday, April 8, 2026
Breaking News: Best of BioWorld Science: Q1Breaking News: Best of BioWorld: Q1Breaking News: Best of BioWorld Science: Q1
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Cancer

Jaguahr Therapeutics reports new AhR antagonists for treatment of cancer

April 30, 2024
A Jaguahr Therapeutics Pte Ltd. patent describes new aryl hydrocarbon receptor (AhR) antagonists reported to be useful for the treatment of cancer.
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Ocular

cGAS inhibitors described in Bellbrook Labs patent

April 30, 2024
Work at Bellbrook Labs LLC has led to the discovery of imidazolyl-alkoxyquinolin-2-amines acting as cyclic GMP-AMP synthase (MB21D1; cGAS) inhibitors.
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Cancer

Hotspot Therapeutics patents CBL-B inhibitors

April 30, 2024
Hotspot Therapeutics Inc. has identified new E3 ubiquitin-protein ligase CBL-B inhibitors reported to be useful for the treatment of cancer.
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Infection

Bluejay Therapeutics identifies new compounds for bacterial and viral infections

April 30, 2024
New indazole pyridone compounds and their prodrugs have been patented by Bluejay Therapeutics Inc.
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Cancer

Prelude Therapeutics patent details CDK inhibitors for cancer

April 30, 2024
Prelude Therapeutics Inc. has described new CDK2/cyclin E2 and CDK4/cyclin D1 inhibitors reported to be useful for the treatment of cancer.
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2D nanoparticles
Drug design, drug delivery & technologies

Repertoire, BMS to develop tolerizing vaccines for autoimmune diseases

April 30, 2024
Repertoire Immune Medicines Inc. has entered a multiyear strategic collaboration with Bristol Myers Squibb Co. (BMS) to develop tolerizing vaccines for up to three autoimmune diseases.
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Cancer cells under magnifying glass
Cancer

CKD Pharm’s c-Met-targeting CKD-703 induces cancer cell death in solid tumors

April 30, 2024
Chong Kun Dang Pharm (CKD Pharm) has presented data on their c-Met-targeting antibody-drug conjugate (ADC) CKD-703 for the treatment of solid tumors. CKD-703 was designed based on site-specific conjugation, with a stable and homogeneous drug-antibody ratio profile.
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Antibody-drug conjugate illustration
Immuno-oncology

AT-2604, an anti-ALPP/ALPPL2 ADC with efficacy and improved safety

April 30, 2024
Researchers from Axcynsis Therapeutics Pte. Ltd. presented the development and preclinical characterization of AT-2604, a novel antibody-drug conjugate (ADC) targeting the placental alkaline phosphatases, ALPP and ALPPL2.
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Drug discovery illustration
Drug design, drug delivery & technologies

Peptidream and Novartis expand peptide discovery collaboration

April 30, 2024
Peptidream Inc. and Novartis Pharma AG have expanded their peptide-drug conjugate discovery collaboration announced in 2019, adding additional peptide radioligand therapies and other programs.
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Natural killer cell attacking cancer cell
Immuno-oncology

IND for Syena’s SY-307 cleared by FDA

April 30, 2024
Replay Holdings LLC and The University of Texas MD Anderson Cancer Center report that the FDA has cleared the IND application for PRAME TCR/IL-15 NK (SY-307), an engineered T-cell receptor natural killer (TCR-NK) cell therapy for relapsed/refractory myeloid malignancies.
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