In a paper published on Feb. 21, 2024, in Science Translational Medicine, researchers from the Versiti Blood Research Institute described how they successfully controlled bleeding for months in hemophilia A models using a siRNA therapy that targeted plasminogen.
Open Source Therapeutics has patented new aromatic substituent-containing (hetero) aryl-imidazole compounds acting as bifunctional epoxide hydrolase 2 (EPHX2; sEH) inhibitors.
Purdue Research Foundation, The Brigham and Women's Hospital Inc., the University of California Oakland and University of Utah have developed platinum complexes for the treatment of cyanide poisoning.
Fochon Biosciences Ltd. has identified apoptosis regulator Bcl-2 (D103E mutant) inhibitors reported to be useful for the treatment of autoimmune disease and cancer.
Researchers from Astrazeneca plc and affiliated organizations have described the discovery and preclinical evaluation of casitas B-lymphoma proto-oncogene-b (Cbl-b) inhibitors as novel anticancer candidates.
Plexin domain containing 2 (PLXDC2) is expressed on the surface of several cell types, such as macrophages, dendritic or epithelial cells. Its activation reduces oxidative stress and rebalances the immune response and decreases inflammation. Its activation has been seen to improve disease severity in models of rheumatoid arthritis, while its blockade or loss exacerbates the severity of dextran sulfate sodium (DSS)-induced colitis. Researchers hence tested the PLXDC2 agonist PX-04 (Landos Biopharma Inc.) in a DSS-induced murine model of colitis.
Clearmind Medicine Inc. has received approval from Israel’s Ministry of Health to initiate a phase I/IIa trial of CMND-100 oral capsules for alcohol use disorder (AUD). The multinational trial in healthy volunteers and AUD subjects will be conducted in Israel and the U.S.
At the ongoing European Crohn’s and Colitis Organization (ECCO) meeting, researchers from Kangpu Biopharmaceuticals Ltd. presented efficacy data on KPG-818, a lenalidomide analogue, in a mouse model that recapitulates Crohn’s disease and ulcerative colitis.
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