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BioWorld - Saturday, May 9, 2026
Breaking News: Read BioWorld's AACR 2026 coverageBreaking News: Read BioWorld's AACR 2026 coverageBreaking News: Best of BioWorld: Q1
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Pain illustration
Neurology/psychiatric

KHN-702 as a potent nonopioid analgesic

April 24, 2026
No Comments
Chengdu Kanghong Pharmaceutical Group Co. Ltd. is developing a nonopioid Nav1.8 inhibitor, KHN-702. The effects of KHN-702 were evaluated both in vitro and in vivo, in a plantar incision pain model, and results were presented at the recent American Academy of Neurology meeting in Chicago.
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Illustration highlighting the adrenal glands and kidneys
Cancer

NEO-811 overcomes HIF resistance in renal cancer

April 24, 2026
No Comments
Neomorph Inc.’s NEO-811 is a molecular glue degrader designed to induce targeted degradation of ARNT and suppress this signaling pathway implicated in clear cell renal cell carcinoma (ccRCC). Targeting ARNT offers a complementary strategy to broadly disrupt oncogenic HIF signaling in ccRCC.
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Vascular system
Cardiovascular

Milestone in Atrium and BMS cardiovascular collaboration

April 24, 2026
No Comments
Atrium Therapeutics Inc. has earned a $15 million development milestone payment from Bristol Myers Squibb Co. (BMS) for the successful delivery of a development candidate for the first licensed compound targeting a cardiology indication under the companies’ ongoing collaboration.
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Coins and seedling
Hematologic

Seed funding at Ferrosa Therapeutics

April 24, 2026
No Comments
Ferrosa Therapeutics AG has announced a $3.5 million seed financing to support the development of a first-in-class bispecific antibody (FRS-101) to treat anemia of inflammation across chronic kidney disease, autoimmune disease and oncology indications.
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Illustration of a tumor
Cancer

Detecting the invisible: minimal residual disease at AACR 2026

April 24, 2026
By Mar de Miguel
No Comments
Minimal residual disease (MRD) has become a central concept in modern oncology, reshaping how clinicians evaluate response, relapse risk and treatment precision. As increasingly sensitive technologies reveal traces of cancer that persist after therapy, MRD is emerging as both a biological challenge and a clinical opportunity, especially as new data illuminate its complexity across hematologic and solid tumors. This topic was addressed at the 2026 American Association for Cancer Research (AACR) annual meeting.
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Neurology/psychiatric

Chengdu Mfs Pharma synthesizes new compounds for pain

April 23, 2026
Chengdu Mfs Pharma Co. Ltd. has prepared and tested compounds for the potential treatment of pain, sleep disorder and status epilepticus epilepsy as well as for use as an anesthetic.
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Cancer

Fosun Pharma discovers new PKMYT1 inhibitors

April 23, 2026
Shanghai Fosun Pharmaceutical Industry Development Co. Ltd. has patented Myt1 kinase (PKMYT1) inhibitors reported to be useful for the treatment of cancer.
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Immuno-oncology

Mabwell discloses new ADAM9-targeting ADCs

April 23, 2026
Mabwell (Shanghai) Bioscience Co. Ltd. has synthesized antibody-drug conjugates comprising antibody or antigen-binding fragment targeting disintegrin and metalloproteinase domain-containing protein 9 (ADAM9) covalently linked to a cytotoxic drug. They are described as potentially useful for the diagnosis and/or treatment of cancer.
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Cancer

Avacta Life Sciences patents FAP-activated camptothecin conjugates

April 23, 2026
Avacta Life Sciences Ltd. has disclosed drug conjugates consisting of a fibroblast activation protein-α (FAPα) cleavable moiety bonded to camptothecin derivatives through a linker that are potentially useful for the treatment of cancer, inflammation and fibrosis.
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Cancer

Hetero Labs divulges new tyrosine kinase inhibitors

April 23, 2026
Hetero Labs Ltd. has reported tyrosine kinase inhibitors that are potentially useful for the treatment of cancer.
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