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BioWorld, Clinical
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Taiwan’s Senhwa advancing CK2 candidate against moderate COVID-19

July 29, 2020
By Elise Mak
Senhwa Biosciences Inc., of Taipei, Taiwan, said casein kinase 2 (CK2) is the right target to aim at when developing a COVID-19 therapeutic treatment. The company’s silmitasertib is the only clinical-stage inhibitor of CK2, a kinase recently identified by researchers as being hijacked by SARS-CoV-2.
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Dimerix lead compound meets primary and secondary endpoints in phase IIa FSGS kidney disease trial

July 29, 2020
By Tamra Sami
PERTH, Australia – Melbourne-based Dimerix Ltd.’s stock shot up nearly 20% on the news that its lead compound, DMX-200, met primary and secondary endpoints in a phase IIa trial in patients with rare kidney disease focal segmental glomerulosclerosis (FSGS), according to top-line results.
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In the clinic for July 29, 2020

July 29, 2020
Clinical updates, including trial initiations, enrollment status and data readouts and publications: Abbvie, Auris, Constant, Denali, Dimerix, Genentech, Krystal, Repare, Samus, Sanofi.
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Codagenix plans a human challenge trial to test its COVID-19 vaccine

July 28, 2020
By Lee Landenberger
As Pfizer Inc. and Biontech SE start their massive phase II/III safety and efficacy trial evaluating a single nucleoside-modified messenger RNA candidate from their BNT-162-based vaccine program against SARS-CoV-2, smaller, privately held Codagenix Inc. plans a different approach.
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Two ways about it? Spectrum sorts for cohorts’ purport after NSCLC win

July 28, 2020
By Randy Osborne
The bad cohort 1 news from Spectrum Pharmaceuticals Inc. in late April with poziotinib in the phase II Zenith20 study turned itself around in a stock-boosting way as the Henderson, Nev.-based firm unveiled data from cohort 2.
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Glenmark’s phase III favipiravir study finds drug speeds clinical improvement for some patients

July 28, 2020
By David Ho
HONG KONG – Mumbai, India-headquartered Glenmark Pharmaceuticals Ltd. have released statistically significant top-line results from a phase III trial showing that Fabiflu (favipiravir), an antiviral pyrazine RNA polymerase inhibitor, can treat cases of mild to moderate COVID-19 in four days.
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Moderna searches for the right participants in its phase III COVID-19 trial

July 27, 2020
By Lee Landenberger
Moderna Inc. dosed the first of what could be as many as 30,000 healthy volunteers Monday morning as it began its phase III COVID-19 vaccine trial.
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In the clinic for July 27, 2020

July 27, 2020
Clinical updates, including trial initiations, enrollment status and data readouts and publications: 4D Molecular, Aerie, AI Therapeutics, Amarin, Dalcor, Dare, Destiny, Eyepoint, Immunic, Jcyte, Moderna, NGM, Opthea, Promab, Puma, Rezolute, Rigel, TCR2.
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Cross-section of brain

Daiichi Sankyo hits phase III endpoint for prasugrel, inks deal with Gustave Roussy

July 24, 2020
By David Ho and Gina Lee
HONG KONG – Tokyo-based Daiichi Sankyo Co. Ltd. has hit its goals in a phase III study testing the use of prasugrel hydrochloride in thrombotic stroke patients.
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In the clinic for July 24, 2020

July 24, 2020
Clinical updates, including trial initiations, enrollment status and data readouts and publications: Alector, Amgen, Chi-Med, Cytomx, Northwest, Noxxon, Polarityte, Theratechnologies, UCB.
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