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Home » Keywords » long noncoding RNA

Items Tagged with 'long noncoding RNA'

ARTICLES

Illustration of prescription pill bottle with DNA on the label.
Neurology/Psychiatric

Gene expression study gives clues to pain insensitivity syndrome

May 25, 2023
By Anette Breindl
Researchers have used cell culture experiments to understand how gene expression was affected in a patient with a rare pain insensitivity syndrome, and have identified a network of hundreds of genes whose expression was changed compared to sex-matched controls. Published online in the journal Brain on May 23, 2023, the research is one step toward translating a rare mutation into medications that could provide benefits for common ailments.
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RNA strand
Newco news

Haya targets lncRNA for tissue-specific fibrosis drugs

Feb. 3, 2023
By Cormac Sheridan
Could long non-coding RNAs be the key to developing organ-specific antifibrotic drugs that only mediate their effects in disease-related contexts? That’s the intriguing hypothesis that Haya Therapeutics SA has set out to explore, and its lead program, in heart failure caused by non-obstructive hypertrophic cardiomyopathy, is now in IND-enabling studies. A first clinical trial is pencilled in for late 2024 or early 2025.
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Female sitting on floor in dark room
Biomarkers

FEDORA, a long noncoding RNA, regulates depression in women

Dec. 5, 2022
By Mar de Miguel
Scientists from the Icahn School of Medicine at Mount Sinai have found a sexual dimorphism of depression based on the different expression of a molecule that could be developed as a therapeutic strategy. “There is a big sex difference in depression. Women are much more likely to have depression than men. They tend to have different subsets of symptoms. They tend to respond better to different antidepressants, and the depression tends to be more severe,” Orna Issler, the first author of the study and a postdoctoral researcher at the Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, told BioWorld. Their project, directed by Eric Nestler, a professor of neuroscience and director of the Friedman Brain Institute at the Icahn School of Medicine at Mount Sinai, had the aim to understand the biology of these sex differences of depression and to find therapeutic targets for it.
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RNA

lncRNA HULC linked to phenylketonuria prevention, HULC-mimetics show therapeutic promise

Aug. 13, 2021
By W. Todd Penberthy
Sometimes highly impactful serendipitous discoveries are made when performing genetic loss-of-function studies that were initially focused on putative tumor suppressors or other hypotheses.
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Cancer cell and DNA

Tumor suppressor p53 is inactivated by lncRNA

July 16, 2021
By John Fox
A long noncoding RNA (lncRNA), the RNA component of mitochondrial RNA-processing endoribonuclease, was shown to promote the growth and proliferation of colorectal cancer cells by inhibiting activity of the tumor suppressor protein p53 in a Chinese study led by oncologists Fudan University Shanghai Cancer Center.
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Amaroq Theraeutics launches with NZ$14M seed funding to develop long non-coding RNA therapies

July 9, 2021
By Tamra Sami
PERTH, Australia – Amaroq Therapeutics Ltd., a spinout out of the University of Otago in Dunedin, New Zealand, has launched after securing NZ$14 million (US$9.7 million) in seed funding to develop long non-coding RNAs as therapeutic targets and diagnostic markers to treat breast, colorectal and liver cancer.
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RNA
Newco news

Investors Sineup for seed round to advance Transine’s RNA therapeutics

June 2, 2021
By Nuala Moran
LONDON – In a sizeable seed round for a U.K. biotech, Transine Therapeutics Ltd. has raised £9.1 million (US$12.9 million) to take forward a novel method for up-regulating endogenous protein production using a naturally occurring class of long noncoding RNAs.
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