Sarcomas are generally classified into soft tissue sarcomas, such as fibrosarcoma, and bone sarcomas such as chondrosarcoma, which are rare cancers in adults accounting for about 1% of all cancer diagnoses, while in children the rate goes up to 20% of all cancer cases.
Cholangiocarcinoma includes several biliary malignant tumors that have poor prognosis. Post-translational modifications in proteins lead to abnormal protein dynamics and disturbances that may cause pathology.
Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin cancer with a high mortality rate and characterized by frequent local recurrences and metastases. To identify compounds that could be repurposed to treat MCC, National Institutes of Health (NIH) researchers performed a high-throughput cell viability screen of 3,908 small molecules.
Esophageal cancer, particularly esophageal squamous cell carcinoma (ESCC), is one of the most prevalent digestive malignancies, with a 5-year survival rate of only 20%. Although some cancer immunotherapies based on immune checkpoint inhibitors (ICIs) have shown promise for ESCC, only a minority of patients actually benefit from ICI therapy.
Human antigen R (HuR) controls the stability and translation of several transcripts that are key for metabolism, inflammation and cancer, including TNF-α or MYC. Previous findings have shown the pro-tumorigenic role of HuR in hepatocellular carcinoma (HCC), and its inhibition to be involved in metabolic dysfunction-associated steatohepatitis (MASH).
Researchers from Universitatsklinikum Heidelberg presented data from a study that investigated the role of strawberry notch homolog 1 (SBNO1) in the development of hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA).
The FKBP5 gene encodes FKBP prolyl isomerase 5, a co-chaperone that modulates glucocorticoid signaling and that is expressed in T cells, neurons and in microglial cells in the central nervous system (CNS). The role of FKBP5 in the dysregulation of myeloid cells in the pathogenesis of multiple sclerosis was investigated in a murine model of experimental autoimmune encephalomyelitis.
Scientists from the Lebanese American University investigated the role of acetyl-CoA synthetase short chain family member 2 (ACSS2) in inflammatory bowel disease, including ulcerative colitis and Crohn’s disease.
Researchers from Universidad del País Vasco and affiliated organizations presented data from a study that aimed to investigate the role of macrophage receptor with collagenous structure (MARCO) in intrahepatic cholangiocarcinoma.
