An Australian-led study reported in the January 25, 2021, online edition of NatureImmunology has identified a new immunomodulatory pathway within the gut-lung axis that enhances microbial tyrosine metabolism, which could be targeted to treat or prevent atopic asthma and other inflammatory diseases.
Keeping you up to date on recent developments in oncology, including: Hypoxia a potential marker for recurrent glioblastoma; SCLC subtypes have specific vulnerabilities; Few-shot learning may speed up drug development; New research may move up breast cancer diagnosis.
An international study led by Australian scientists has shown for the first time that the androgen receptor (AR) is a tumor suppressor in estrogen receptor-positive (ER+) metastatic breast cancer, including in endocrine therapy resistance, which supports the use of an AR agonist-based treatment strategy.
Keeping you up to date on recent developments in cardiology, including: Age influences sex-related outcomes following a heart attack; Fried food intake fingered in upped risk of heart disease, stroke; Genetic risk factor for stroke revealed.
The Human Skin Cell Atlas, comprising transcriptomes of 528,253 single cells, shows that cellular processes involved in skin development in embryos are reactivated in inflammatory skin diseases. In addition to suggesting potential new drug targets for atopic dermatitis and psoriasis, the transcriptomes provide a new route to understanding other inflammatory diseases.
Keeping you up to date on recent developments in neurology, including: Personalized neuromodulation technique developed for obsessive-compulsive behavior; Improving pain research with new sensory neuron model; Tau end run prevents memory deficits, but not inflammation; Presenilin mutations affect neuronal stem cells.
Aging is not just wear and tear. It is an active process that is driven, at least in part, by chronic inflammation that is the result of immune cell dysfunction. Now, investigators at Stanford University have identified the metabolic switch underlying immune cell switch from function to dysfunction.
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