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BioWorld - Wednesday, December 31, 2025
Home » Topics » Clinical

Clinical
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Dosey-dough? Wave stumbles vs. Ionis/Roche in HD dance but new 32-mg cohort could unlock gold

Dec. 30, 2019
By Randy Osborne
Shares of Cambridge, Mass.-based Wave Life Sciences Ltd. (NASDAQ:WVE) lost 49.5% of their value, or $7.82, to close at $7.99 as investors learned of top-line data from the ongoing phase Ib/IIa Precision HD2 trial testing WVE-120102 in Huntington’s disease. 
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Staphylococcus aureus

Argentine researchers develop surfaces that could improve medical devices

Dec. 30, 2019
By Sergio Held
BOGOTA, Colombia – Researchers at the National University of Córdoba, in Córdoba, Argentina, have developed a technique to optimize the biofunctions of surfaces and inhibit microorganisms such as Staphylococcus aureus from adhering to and building colonies on solid substrates’ surfaces.
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Springing back: Spring Bank stabilizes after phase IIb halt

Dec. 27, 2019
By Lee Landenberger
The stock at Spring Bank Pharmaceuticals Inc. (NASDAQ:SBPH), after an especially rough Thursday, began healing a bit as investors took in the company’s decision to stop dosing and enrolling patients in its phase IIb Catalyst trials.
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Liver disease

Boehringer Ingelheim quits development of Pharmaxis drug for NASH indication

Dec. 24, 2019
By Tamra Sami
PERTH, Australia – Boehringer Ingelheim GmbH is discontinuing development of BI-1467335 for the treatment of nonalcoholic steatohepatitis (NASH) that it acquired from Sydney-based Pharmaxis Ltd. in 2015.
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High-profile failure hits Stealth's phase III mitochondrial myopathy trial

Dec. 20, 2019
By Michael Fitzhugh
A medicine Stealth Biotherapeutics Inc. has been developing for the potential treatment of primary mitochondrial myopathy (PMM) missed the co-primary endpoints of a key phase III trial, sending company shares (NASDAQ:MITO) down 65.9% to close at $4.75 on Friday.
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guardant-health-G360-12-19.png

Guardant360 liquid biopsy quickly identifies targetable mutations in breast cancer

Dec. 19, 2019
By Annette Boyle
The Guardant360 assay accurately detected genomic alterations that permit patient matching to targeted therapies, according to a presentation of the plasmaMATCH study at the 2019 San Antonio Breast Cancer Symposium. The study is the largest ever performed for a liquid biopsy.
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Boehringer Ingelheim quits development of Pharmaxis drug for NASH indication

Dec. 18, 2019
By Tamra Sami
PERTH, Australia – Boehringer Ingelheim GmbH is discontinuing development of BI-1467335 for the treatment of nonalcoholic steatohepatitis (NASH) that it acquired from Sydney-based Pharmaxis Ltd. in 2015.
Read More

Cautious optimism for Biolinerx’s CXCR4 inhibitor in pancreatic cancer

Dec. 17, 2019
By David Ho
HONG KONG – Israel-based Biolinerx Ltd. has unveiled the latest data from its ongoing phase IIa COMBAT/KEYNOTE-202 study at the European Society of Medical Oncology Immuno-Oncology Congress 2019 which evaluates Biolinerx’s BL-8040.
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Telehealth illustration

Pear Therapeutics, Novartis look to tackle depressive symptoms in MS patients

Dec. 17, 2019
By Liz Hollis
Digital therapeutics have made great strides in recent years, with Pear Therapeutics Inc. playing a key role. Now, the company has reported the dosing of the first patient in part two of a study assessing Pear-006 to address depressive symptoms in multiple sclerosis (MS).
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Telehealth illustration

Pear Therapeutics, Novartis look to tackle depressive symptoms in MS patients

Dec. 17, 2019
By Liz Hollis
Digital therapeutics have made great strides in recent years, with Pear Therapeutics Inc. playing a key role. Now, the company has reported the dosing of the first patient in part two of a study assessing Pear-006 – which Pear Therapeutics is developing in collaboration with Basel, Switzerland-based Novartis AG – to address depressive symptoms in multiple sclerosis (MS).
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