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BioWorld - Friday, September 29, 2023
Home » Topics » Immune, BioWorld MedTech

Immune, BioWorld MedTech
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Blood vessels

Humacyte’s phase II/III tissue graft data prompt talk of a BLA

Sep. 12, 2023
By Lee Landenberger
No Comments
Regenerative tissue developer Humacyte Inc. has posted positive top-line phase II/III results for its Human Acellular Vessel, a tissue-engineered graft consisting entirely of decellularized extracellular matrix, for vascular trauma repair. The data showed higher rates of patency, a measure of the lack of vascular obstruction, when compared to synthetic graft benchmarks.
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DNA double helix with sand hour glass

Biomarker brainteaser: Aging? Or just changing?

Aug. 30, 2023
By Anette Breindl
No Comments
“Change is the only constant” is an ageless truth. In the search for age-related biomarkers, it is also a prosaic confounding factor.

Age-related biomarkers will be critical for the development of antiaging therapeutics. “Nobody is planning to do a life span study in humans,” Eric Verdin told the audience at the 10th Conference on Aging Research and Drug Development in Copenhagen on Monday. “Hence the need for … surrogate markers.”
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Cholesterol plaque in artery
Cardiovascular

T-cell study reveals autoimmune component of atherosclerosis

Feb. 2, 2023
By Mar de Miguel
No Comments
The combination of two sequencing techniques has unveiled features of a subpopulation of cells that could be producing plaques in atherosclerosis. This process is associated with an autoimmune component driven by CD4+ T cells, according to a study from researchers at Leiden University.
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Concept art of DNA, BRCA1/BRCA2 associated ovarian cancer.
Cancer

Alterations in DNA repair genes predict long-term survival in ovarian cancer

Dec. 13, 2022
By Subhasree Nag
No Comments
Ovarian cancer is ordinarily associated with poor survival; patients diagnosed with high-grade serous ovarian carcinoma (HGSC) have an overall survival of about 40% at 5 years and 15% at 10 years. Despite having similar histologic features, HGSC patients often experience highly variable outcomes and the underlying determinants for long-term survival (LTS) are largely unknown. In a study published online in Nature Genetics, a multi-institutional group of researchers tried to determine the molecular differences that drive LTS in patients with HGSC.
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Scanning electron micrograph of a macrophage.
Cancer

Innate immunity can drive radiation-induced abscopal effect

Nov. 23, 2022
By Anette Breindl
No Comments
A combination of radiation therapy and CD47 blockade induced an abscopal effect in animal studies even in animals that lacked T cells, researchers reported in the Nov. 21, 2022, online issue of Nature Cancer. The findings are “the first demonstration of T-cell-independent abscopal response,” co-corresponding author Edward Graves told BioWorld. “We’re not trying to say that all abscopal responses are macrophage-mediated. There are plenty that require T cells,” Graves clarified. But “there is another avenue of abscopal responses that has not been reported. ... All the abscopal literature is about stimulating an adaptive response.”
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Mycobacterium tuberculosis
Infection

IDWeek 2022: Infection prevention during latent diseases

Oct. 24, 2022
By Mar de Miguel
No Comments
At the Saturday, Oct. 22 session, ‘Basic Science: Correlates of protection, immune response and the host-microbe interaction,’ of the IDWeek 2022 infectious disease conference, moderator Luiz Bermudez, professor at Oregon State University, introduced the latest advances to prevent infections with Treponema pallidum during neurosyphilis (NS), Staphylococcus aureus and osteomyelitis, and Mycobacterium tuberculosis during influenza.
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Svante Pääbo with skull
Genetic/Congenital

From ancient DNA, a Nobel Prize, and perhaps modern drug targets

Oct. 3, 2022
By Mar de Miguel and Anette Breindl
No Comments
The Nobel Prize in Physiology or Medicine 2022 was awarded to Svante Pääbo today "for his discoveries concerning the genomes of extinct hominins and human evolution." Pääbo, who is currently the director of the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, and his colleagues overcame extreme technical challenges to sequence the DNA of ancient hominids – because after tens of thousands of years, there is no such thing as aging well for DNA.
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Microbiome illustration

Bringing back butyrate is antigen-agnostic approach to food allergies

Aug. 24, 2022
By Anette Breindl
No Comments
Treating mice with butyrate, a short-chain fatty acid that is normally produced by beneficial gut microbes, prevented anaphylactic shock in allergic mice when they were exposed to peanuts after treatment. It also reduced inflammation in animals with colitis.
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Multiple sclerosis

Study finds targets of T-cell response in multiple sclerosis

April 28, 2022
By Anette Breindl
No Comments
Screening a panel of potential autoantigens, investigators at the Karolinska Institute have identified four autoantigens that are targeted by the T cells of multiple sclerosis patients.
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Human anatomy

Sex disparities of lupus recapitulated in mouse model

April 25, 2022
By Anette Breindl
No Comments
A new animal model of systemic lupus erythematosus (lupus) could be useful for understanding the disparity of the disorder, which is vastly more common in women than men.
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