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BioWorld - Tuesday, January 13, 2026
Home » Topics » Drugs

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Pills and bottle

Coronavirus outbreak in China sparks fears of disruption for global drug supplies

Feb. 11, 2020
By Elise Mak
BEIJING – China’s partial shutdown caused by the 2019-nCoV coronavirus outbreak has sparked global fears of a disrupted supply chain of active pharmaceutical ingredients (API), as the country is a major exporter. Drugs that many depend on, such as ibuprofen and acarbose, could be affected.
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HKEX building

Akeso refiles IPO with HKEX amid coronavirus outbreak

Feb. 11, 2020
By Elise Mak
BEIJING – Zhongshan-based Akeso Inc., which focuses on bispecific antibodies, is again seeking pre-revenue listing on the Hong Kong Stock Exchange (HKEX), after its first IPO attempt failed to go through in December. The move comes at a time when analysts believe the coronavirus outbreak is weighing on the city’s IPO market. The second application, submitted on Feb. 3, was again supported by Morgan Stanley and J.P. Morgan. The clinical-stage biotech is reportedly seeking $300 million to support its R&D through the IPO, particularly its core asset, AK-104, a PD-1/CTLA4 bispecific antibody.
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HKEX building

Akeso refiles IPO with HKEX amid coronavirus outbreak

Feb. 10, 2020
By Elise Mak
BEIJING – Zhongshan-based Akeso Inc., which focuses on bispecific antibodies, is again seeking pre-revenue listing on the Hong Kong Stock Exchange (HKEX), after its first IPO attempt failed to go through in December. The move comes at a time when analysts believe the coronavirus outbreak is weighing on the city’s IPO market.
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Roche, Lilly drugs fail to slow decline in early onset AD

Feb. 10, 2020
By Michael Fitzhugh
A high-profile test of two experimental medicines in people with autosomal dominant Alzheimer’s disease (ADAD), a rare inherited form of the disease, found that neither drug significantly slowed rates of cognitive decline vs. placebo, the primary endpoint.
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Anxious balance: Biohaven’s troriluzole misses its primary endpoint while rimegepant could be a blockbuster

Feb. 10, 2020
By Lee Landenberger
Top-line results from Biohaven Pharmaceutical Holding Co.’s phase III trial of troriluzole against placebo in treating generalized anxiety disorder (GAD) failed to hit its primary endpoint, prompting the company CEO to say the poor results support halting development plans for the glutamate modulator as a monotherapy in GAD.
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Diabetes glucose monitor

Vtv scores phase II TD in T1D as Alzheimer’s bid RAGEs against dying of light

Feb. 10, 2020
By Randy Osborne
With the Simpliciti-T1 phase II trial testing new-mechanism TTP-399 as adjunct therapy in type 1 diabetes (T1D), High Point, N.C.-based Vtv Therapeutics Inc. nailed the HbA1c endpoint with none of the safety concerns foiling developers of type 2 diabetes (T2D) drugs who sought to broaden their labels.
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Oncology: Enhertu, liso-cel, sacituzumab govitecan

Is it finally their time? Two ADCs for cancer make the blockbuster list

Feb. 10, 2020
By Lee Landenberger
Two of three oncology drugs selected for blockbuster status in the Cortellis Drugs to Watch analysis are antibody-drug conjugates (ADCs), highly targeted cancer therapies designed to leave the healthy cells be and zap the bad ones. What once was a dead end for development has morphed into a competitive space with 57 ADC candidates for cancer indications in phase I or later trials, according to Cortellis.
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Inclusive research brings scientific, monetary riches: Inclisiran

Feb. 10, 2020
By Anette Breindl
Inclisiran’s inclusion on the 2020 Cortellis Drugs to Watch list is an example of target discovery possibilities hiding in plain sight – if companies and institutions are willing to put effort into increasing sample diversity in genomic research.
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Metabolic: Inclisiran, Rybelsus

Novartis’ high ‘steaks’ with inclisiran in FH; optimism for Rybelsus in diabetes

Feb. 10, 2020
By Randy Osborne

The less-frequent dosing regimen of Basel, Switzerland-based Novartis AG’s cholesterol therapy, inclisiran, under development in the hands of subsidiary The Medicines Co., positions the small interfering RNA (siRNA) drug to take on marketed proprotein convertase subtilisin/kexin type 9 (PCSK9)-targeting antibodies as well as statins in the busy therapeutic space. Statins are the gold standard now, but about 80% of patients don’t reach their lipid goals.


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Inflammatory/Immune: Filgotinib

Filgotinib looks to JAK up sales with multiple indications

Feb. 10, 2020
By Brian Orelli
Filgotinib (GLPG-0634) has the potential to be a blockbuster drug, according to Cortellis Drugs to Watch analysis, but it may take a few approvals in various indications to reach the coveted mark of $1 billion in annual sales.
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