Fox Chase Chemical Diversity Center Inc. has described novel bis-amide containing compounds reported to be useful for the treatment of fungal infections.
Japan's National Center for Global Health and Medicine (NCGM) has divulged 3C-like proteinase (3CLpro; Mpro; nsp5) (SARS-CoV-2; COVID-19 virus) inhibitors reported to be useful for the treatment of SARS-CoV-2 infections (COVID-19).
Aphiotx Inc. has identified sulfamoyl benzene derivatives acting as pannexin-1 (PANX1; MRS1) inhibitors reported to be useful for the treatment of opioid withdrawal.
Sichuan Haisco Pharmaceutical Co. Ltd. has synthesized selective estrogen receptor degradation inducers (SERDs) reported to be useful for the treatment of cancer.
Denali Therapeutics Inc. has disclosed NLRP3 inflammasome inhibitors reported to be useful for the treatment of stroke, gout, multiple sclerosis, Alzheimer's disease, hypertension, silicosis, graft-versus-host disease and nonalcoholic steatohepatitis (NASH).
Obesity is an important cause of death worldwide, and it is defined as a body mass index >30 kg/m2. Genome-wide association studies have been successful at identifying genomic loci tied to obesity.
Evaxion Biotech A/S and Pantherna Therapeutics GmbH have announced preclinical proof of concept for the combination of the two companies' key technologies.
Researchers from Yale School of Medicine, along with Helsinki University Hospital and University of Helsinki, have reported data from a study that aimed to assess the effects of a common variant in hydroxysteroid 17-β dehydrogenase 13 (HSD17B13 rs72613567-A) in the liver.
Spinal-bulbar muscular atrophy (SBMA), also called Kennedy disease, is an X-linked genetic disorder in which the loss of motor neurons affects the parts of the nervous system that control voluntary muscle movement.
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