Biondvax Pharmaceuticals Ltd. has reported statistically significant efficacy results from an in vivo proof-of-concept study of its innovative inhaled nanosized antibody (NanoAb) COVID-19 therapy.
Endophilin A2 (EndoA2) is a member of the endophilin A family, and is involved in the regulation of neurological and cardiovascular diseases, as well as tumor formation. Researchers from the Second Affiliated Hospital of Guangzhou Medical University assessed the role of EndoA2 in renal fibrosis.
Context Therapeutics Inc. has selected CTIM-76, a T cell-engaging bispecific antibody, as its lead clinical development candidate to target Claudin-6 (CLDN6)-positive cancers. Resulting from a research collaboration and licensing agreement with Integral Molecular Inc., CTIM-76 is a CLDN6 x CD3 bispecific antibody that incorporates a highly selective CLDN6 binding arm and a CD3 binding single-chain Fv domain in an IgG format with a silenced Fc that is designed to be functionally monovalent to avoid aberrant T-cell activation and to enhance the safety profile.
Does cancer cause autoimmune disease or is it the other way around? In looking at the question of which comes first, the chicken or the egg, researchers at the Garvan Institute of Medical Research in Australia found that a genetic mutation that alters immune cells in leukemia is behind certain autoimmune disorders.
A computational platform that used single-cell RNA sequencing (scRNA-seq) data could quickly predict the best chemical compounds to use to convert cells from one type into another for use in research or cell therapies. The work, published in the Nov. 17, 2022, issue of Stem Cell Reports, was a collaboration between the lab of Hongkui Deng, a professor and director of the Key Laboratory of Cell Proliferation and Differentiation at Peking University in Beijing, and the lab of Antonio del Sol, a professor at the Luxembourg Centre for Systems Biomedicine at the University of Luxembourg.
Taisho Pharmaceutical Co. Ltd. has synthesized sulfonamide-containing peptides acting as MMP-7 (matrilysin) inhibitors reported to be useful for the treatment of cancer.
Scientists at the University of Turin and the University of Pisa have identified NLRP3 inflammasome inhibitors reported to be useful for the treatment of inflammation, neurodegeneration, cancer, cardiovascular disorders, and autoimmune and metabolic disease.
Benevolentai Bio Ltd. has discovered imidazopyridazine derivatives acting as high-affinity nerve growth factor receptor (NTRK1) and/or BDNF/NT-3 growth factor receptor (NTRK2) and/or NT-3 growth factor receptor (NTRK3) inhibitors reported to be useful for the treatment of atopic dermatitis.
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