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Drug design, drug delivery and technologies
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Drug design, drug delivery & technologies

Letting lab mice run wild improves preclinical translatability

Sep. 2, 2025
By Anette Breindl
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“The impoverished laboratory environment in which mice and rats are maintained has been very good at increasing experimental replicability,” Steven Austad told the audience at the 12th Aging Research & Drug Discovery Meeting (ARDD) in Copenhagen last week. “But at the cost of sacrificing translational relevance.”
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Futuristic medicine research illustration with petri dishes and pipette
Infection

Generative AI comes up with novel antibiotic structures

Aug. 22, 2025
By Anette Breindl
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Researchers at the Massachusetts Institute of Technology have developed a generative AI model that was able to generate novel antibiotic structures from either chemical fragments or de novo, starting from ammonia, methane, water or no starting point at all. In a study that was published online in Cell, the team tested two dozen of more than 10 million structures that were proposed as potential antibiotics by the model.
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Futuristic medicine research illustration with petri dishes and pipette

Generative AI comes up with novel antibiotic structures

Aug. 21, 2025
By Anette Breindl
No Comments
Researchers at the Massachusetts Institute of Technology have developed a generative AI model that was able to generate novel antibiotic structures from either chemical fragments or de novo, starting from ammonia, methane, water or no starting point at all. In a study that was published online in Cell, the team tested two dozen of more than 10 million structures that were proposed as potential antibiotics by the model.
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Futuristic medicine research illustration with petri dishes and pipette
Infection

Generative AI comes up with novel antibiotic structures

Aug. 20, 2025
By Anette Breindl
No Comments
Researchers at the Massachusetts Institute of Technology have developed a generative AI model that was able to generate novel antibiotic structures from either chemical fragments or de novo, starting from ammonia, methane, water or no starting point at all. In a study that was published online in Cell, the team tested two dozen of more than 10 million structures that were proposed as potential antibiotics by the model.
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Neurology/psychiatric

Delivery system for therapeutic antibodies against amyloid-β

Aug. 19, 2025
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One of the major obstacles to treating neurological disorders such as Alzheimer’s disease is the blood-brain barrier: drugs that are injected into the circulation usually do not enter the brain effectively. Researchers at Denali Therapeutics Inc., Biogen Inc. and the University of Minnesota have devised a vehicle for transporting antibodies against amyloid-β that can bypass the blood-brain barrier by binding to the transferrin receptor, which is expressed much more abundantly in capillaries than in arteries.
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Proteina CEO Yoon Tae-young giving a talk

Proteina’s PPI Landscape to help reshape antibody drug design

Aug. 18, 2025
By Marian (YoonJee) Chu
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“Our mission is to apply our protein-protein interaction (PPI) big data-generation platform to create novel antibody therapeutics,” Proteina Co. Ltd. CEO Yoon Tae-young recently told BioWorld. “We have been working to build a proprietary technology platform for more than 15 years,” Yoon said, “and we take pride in the fact that we made our own technology platform, instead of running a company based on licensed-in technology.”
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