PERTH, Australia – The fight against diffuse intrinsic pontine glioma may finally see some progress, after experiments using 3D models of the tumor in animal studies showed that a combination therapy of the polyamine inhibitor AMXT-1501 (Aminex Therapeutics Inc.) and the ornithine decarboxylase 1 inhibitor difluoromethylornithine could eradicate cancer cells.
BioWorld looks at translational medicine, including: Classifying variants of unknown significance; Platelets release antigenic DNA in lupus; Intracranial samples give glimpse into stroke response.
Organoids grown from cholangiocytes – the epithelial cells of the bile duct – are poised to be used in ex vivo cell therapy to increase the number of donated livers that are suitable for transplant, and also for direct bile duct repairs.
BioWorld looks at translational medicine, including: Metabolic changes are antibiotic resistance mechanism; Tumor neoantigens can inhibit immune response; Chromosome organization machinery linked to DNA repair.
Twenty years to the month after the completion of the draft sequence of the human genome, the Human Genome Project and follow-on projects like The Cancer Genome Atlas are underpinning advances in precision medicine.
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