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BioWorld - Saturday, April 17, 2021
Home » Topics » Clinical

Clinical
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Blood cells and bacteria

Sepsis study may yield new treatment strategies

April 2, 2020
By John Fox
No Comments
Indian scientists have discovered a previously unknown mechanism underlying life-threatening sepsis and proposed a new treatment strategy centered upon cell-free chromatin (cfCh), they reported in the March 4, 2020, edition of PLOS ONE. Notably, they showed that sepsis could be caused by cfCh released from dying host cells following microbial infection.
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Lung cancer illustration

Another COVID-19 casualty: Ose shutters phase III Tedopi trial in NSCLC despite positive interim analysis

April 2, 2020
By Cormac Sheridan
No Comments
DUBLIN – Ose Immunotherapeutics SA finds itself in the difficult place of hitting the primary endpoint of the first part of a phase III trial of Tedopi, a therapeutic vaccine, in non-small-cell lung cancer (NSCLC) while having to terminate the study without completing the crucial second part.
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Blood cells and bacteria

Sepsis study may yield new treatment strategies

April 1, 2020
By John Fox
No Comments
Indian scientists have discovered a previously unknown mechanism underlying life-threatening sepsis and proposed a new treatment strategy centered upon cell-free chromatin (cfCh), they reported in the March 4, 2020, edition of PLOS ONE. Notably, they showed that sepsis could be caused by cfCh released from dying host cells following microbial infection.
Read More
Tuberculosis

South Korea’s Qurient posts phase II success with telacebec in drug-resistant TB

March 31, 2020
By David Ho
No Comments
HONG KONG – Phase II data of South Korea-based Qurient Co. Ltd.’s novel antibiotic candidate may offer hope that the first universal regimen to treat tuberculosis (TB) regardless of drug resistance status has been found.
Read More
3-31-Medtronic-Evolut-PRO.png

Excellent outcomes for Medtronic Evolut TAVR in low-risk bicuspid AVS patients

March 31, 2020
By Annette Boyle
No Comments
Results of a study presented at the American College of Cardiology's Annual Scientific Session on March 29 demonstrated “excellent” outcomes following transcatheter aortic valve replacement (TAVR) using the Medtronic plc Evolut in low surgical risk patients with bicuspid aortic valve stenosis.
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Cancer cell and DNA

Grail liquid biopsy test broadly detects cancers, particularly aggressive ones, in large study

March 31, 2020
By Stacy Lawrence
No Comments
Systematic detection of cancer at earlier stages at a population level could remodel how the medical profession approaches cancer treatment, establishing the potential to reduce cancer mortality by almost one-quarter. That’s according to an analysis based on the latest data from Grail Inc.'s Circulating Cell-free Genome Atlas (CCGA) study.
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Akero arrow sights gold, nearing pivot point in NASH?

March 31, 2020
By Randy Osborne
No Comments
Akero Therapeutics Inc. rolled out stellar non-COVID-19 (for a change) clinical news with long-acting fibroblast growth factor 21 (FGF21) analogue AKR-001 in biopsy-confirmed nonalcoholic steatohepatitis (NASH), but even in liver disease the pandemic became part of the discussion.
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3-30-Medtronic-Symplicity-Spyral.png

Renal denervation significantly reduces untreated hypertension

March 30, 2020
By Annette Boyle
No Comments
Results of the pivotal Spyral-HTN OFF MED study presented at the American College of Cardiology's Annual Scientific Session on March 29 demonstrated significant reduction in blood pressure three months after renal denervation (RDN) in patients with unmedicated hypertension.
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3-30-fractyl-revita.png

Fractyl offers mechanism of action results, as it aims for intestinal resurfacing U.S. pivotal trial in 2020

March 30, 2020
By Stacy Lawrence
No Comments
Fractyl Laboratories Inc. has released data from a mixed meal tolerance study that shows its procedure for resurfacing the duodenal mucosa improves fasting blood glucose and reduces liver fat.
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Tuberculosis

South Korea’s Qurient posts phase II success with telacebec in drug-resistant TB

March 27, 2020
By David Ho
No Comments
HONG KONG – Phase II data of South Korea-based Qurient Co. Ltd.’s novel antibiotic candidate may offer hope that the first universal regimen to treat tuberculosis (TB) regardless of drug resistance status has been found.
Read More
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