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BioWorld - Monday, March 8, 2021
Home » Topics » Clinical

Clinical
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Springing back: Spring Bank stabilizes after phase IIb halt

Dec. 27, 2019
By Lee Landenberger
No Comments
The stock at Spring Bank Pharmaceuticals Inc. (NASDAQ:SBPH), after an especially rough Thursday, began healing a bit as investors took in the company’s decision to stop dosing and enrolling patients in its phase IIb Catalyst trials.
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Liver disease

Boehringer Ingelheim quits development of Pharmaxis drug for NASH indication

Dec. 24, 2019
By Tamra Sami
No Comments
PERTH, Australia – Boehringer Ingelheim GmbH is discontinuing development of BI-1467335 for the treatment of nonalcoholic steatohepatitis (NASH) that it acquired from Sydney-based Pharmaxis Ltd. in 2015.
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High-profile failure hits Stealth's phase III mitochondrial myopathy trial

Dec. 20, 2019
By Michael Fitzhugh
No Comments
A medicine Stealth Biotherapeutics Inc. has been developing for the potential treatment of primary mitochondrial myopathy (PMM) missed the co-primary endpoints of a key phase III trial, sending company shares (NASDAQ:MITO) down 65.9% to close at $4.75 on Friday.
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guardant-health-G360-12-19.png

Guardant360 liquid biopsy quickly identifies targetable mutations in breast cancer

Dec. 19, 2019
By Annette Boyle
No Comments
The Guardant360 assay accurately detected genomic alterations that permit patient matching to targeted therapies, according to a presentation of the plasmaMATCH study at the 2019 San Antonio Breast Cancer Symposium. The study is the largest ever performed for a liquid biopsy.
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Boehringer Ingelheim quits development of Pharmaxis drug for NASH indication

Dec. 18, 2019
By Tamra Sami
No Comments
PERTH, Australia – Boehringer Ingelheim GmbH is discontinuing development of BI-1467335 for the treatment of nonalcoholic steatohepatitis (NASH) that it acquired from Sydney-based Pharmaxis Ltd. in 2015.
Read More

Cautious optimism for Biolinerx’s CXCR4 inhibitor in pancreatic cancer

Dec. 17, 2019
By David Ho
No Comments
HONG KONG – Israel-based Biolinerx Ltd. has unveiled the latest data from its ongoing phase IIa COMBAT/KEYNOTE-202 study at the European Society of Medical Oncology Immuno-Oncology Congress 2019 which evaluates Biolinerx’s BL-8040.
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Telehealth illustration

Pear Therapeutics, Novartis look to tackle depressive symptoms in MS patients

Dec. 17, 2019
By Liz Hollis
No Comments
Digital therapeutics have made great strides in recent years, with Pear Therapeutics Inc. playing a key role. Now, the company has reported the dosing of the first patient in part two of a study assessing Pear-006 to address depressive symptoms in multiple sclerosis (MS).
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Telehealth illustration

Pear Therapeutics, Novartis look to tackle depressive symptoms in MS patients

Dec. 17, 2019
By Liz Hollis
No Comments
Digital therapeutics have made great strides in recent years, with Pear Therapeutics Inc. playing a key role. Now, the company has reported the dosing of the first patient in part two of a study assessing Pear-006 – which Pear Therapeutics is developing in collaboration with Basel, Switzerland-based Novartis AG – to address depressive symptoms in multiple sclerosis (MS).
Read More

Adamas’ MS therapy hits primary endpoint, and yet it …

Dec. 17, 2019
By Lee Landenberger
No Comments
While the market gave Adamas Pharmaceuticals Inc. shares a thrashing Tuesday, newly installed CEO Neil McFarlane wouldn’t call it quits on the data generated from the phase III of ADS-5102, the Inroads study for treating multiple sclerosis patients with walking impairment.
Read More
Lungs

What’s afta Trikafta? Proteostasis on the skids as phase II in CF ‘underwhelms’

Dec. 17, 2019
By Randy Osborne
No Comments
Proteostasis Therapeutics Inc. CEO Meenu Chhabra pointed to a “new reality in cystic fibrosis [CF] research” faced by her firm and others: the challenge of enrolling the best patients.
Read More
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