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BioWorld - Friday, June 20, 2025
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Ocular

CTX-114 enhances surface binding and function of complement factor H

May 13, 2025
No Comments
Among the most significant genetic risk factors for age-related macular degeneration is the Y402H variant of complement factor H, which, along with its splice isoform FHL-1, impairs binding to the retinal surface.
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Digital cancer cells illustration
Immuno-oncology

Integrating AI-based neoantigen prediction and APC-targeted delivery to enhance cancer immunotherapy

May 12, 2025
No Comments
Traditional neoantigen prediction methods primarily rely on HLA-peptide binding databases, often producing false positives. This challenge highlights the need for improved strategies to identify truly immunogenic neoantigens. Neoantigen-based cancer vaccines have shown promising efficacy in recent clinical trials for treating solid tumors, offering a potential solution.
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Immune checkpoint inhibitors illustration of PD-1, CTLA-4 and PD-L1.
Immuno-oncology

KGX-103 exerts antitumoral activity in vivo in A375 melanoma model

May 12, 2025
No Comments
Both IL-15 and IL-2 are good options for cancer therapy, but IL-15 is considered superior due to lower vascular endothelial toxicity, stronger ability to expand natural killer and CD8+ T cells and weaker stimulation of T regulatory cells, but it has a short half-life and exerts severe adverse effects.
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Cancer

HW-321005, a novel KAT6A/6B inhibitor with strong antiproliferative activity

May 12, 2025
No Comments
KAT6A and its paralogue KAT6B are histone acetyltransferases whose overexpression is linked to poor prognosis in ER+/HER2- breast cancer and other types of tumors.
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Endocrine/metabolic

GLP-1/GDF15 dual agonist reduces inflammation and fibrosis in MASH

May 12, 2025
No Comments
Beijing QL Biopharmaceutical Co. Ltd. has presented preclinical data on their GLP-1/GDF15 dual agonist QL-1005 for the potential treatment of inflammation and fibrosis in murine models of metabolic dysfunction-associated steatohepatitis (MASH) and chemically induced liver fibrosis.
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Liver illustration
Endocrine/metabolic

Liver is also immune organ, influenced by microbiome

May 12, 2025
By Anette Breindl
No Comments
Immunity is not a function most people particularly associate with the liver. But because of its connection to the gut, the liver is exposed to bacterial metabolites as few other organs are. And when either the liver or the gut is not functioning well, it can adversely affect immunity as well. The liver is connected to the gut via both the biliary system and the portal vein. Those two conduits allow metabolites from the gut microbiome to influence what’s going on in the liver. Both liver and gut damage can affect this communication for the worse. And surprisingly, one of the consequences is immune dysfunction.
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Immuno-oncology

SYS-6041 shows promise for treating FOLR1-expressing cancers

May 9, 2025
No Comments
Folate receptor α (FOLR1) is highly expressed in the surface of tumoral cells in several cancer types, while it shows limited expression in normal tissues. CSPC Pharmaceutical Group Ltd. has developed a next-generation antibody-drug conjugate (ADC) targeting FOLR1 – SYS-6041 – for the treatment of mid-to-low FOLR1-expressing tumors.
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3D illustration and light micrograph of lung cancer.
Immuno-oncology

mRNA-based cancer vaccine targeting mutated EGFR shows antitumor efficacy

May 9, 2025
No Comments
Drug resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors, occurring via secondary mutations or bypass pathways, is frequent among non-small-cell lung cancer patients.
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Immuno-oncology

Anti-CLDN6 QLS-5132 found to have broader therapeutic window

May 9, 2025
No Comments
Claudin-6 (CLDN6) is a protein found in the tight junctions of epithelial cells to modulate their permeability and barrier function, among other actions.
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Illustration of human eye
Ocular

SBT-272 confers neuroprotection in experimental glaucoma

May 9, 2025
No Comments
The progression of neurodegeneration during experimental glaucoma is tied to the early degradation of anterograde transport along retinal ganglion cells to central brain targets, which is followed by frank optic nerve degeneration.
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